Investigation of chromosome Y loss in men with schizophrenia

Takashi Hirata, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Atsushi Kimura, Tadasu Horai, Ichiro Sora Department of Psychiatry, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe, Japan Background: Life expectancy is 10–20 years lower in patients w...

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Autores principales:	Hirata T, Hishimoto A, Otsuka I, Okazaki S, Boku S, Kimura A, Horai T, Sora I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	loss of chromosome Y schizophrenia disease duration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/05afedf577054a2eadb57245331cd93e
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spelling	oai:doaj.org-article:05afedf577054a2eadb57245331cd93e2021-12-02T11:34:29ZInvestigation of chromosome Y loss in men with schizophrenia1178-2021https://doaj.org/article/05afedf577054a2eadb57245331cd93e2018-08-01T00:00:00Zhttps://www.dovepress.com/investigation-of-chromosome-y-loss-in-men-with-schizophrenia-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Takashi Hirata, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Atsushi Kimura, Tadasu Horai, Ichiro Sora Department of Psychiatry, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe, Japan Background: Life expectancy is 10–20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. Materials and methods: The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Results: There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03–1.19]). Conclusion: According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia. Keywords: loss of chromosome Y, schizophrenia, disease durationHirata THishimoto AOtsuka IOkazaki SBoku SKimura AHorai TSora IDove Medical Pressarticleloss of chromosome Yschizophreniadisease durationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2115-2122 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	loss of chromosome Y schizophrenia disease duration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	loss of chromosome Y schizophrenia disease duration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hirata T Hishimoto A Otsuka I Okazaki S Boku S Kimura A Horai T Sora I Investigation of chromosome Y loss in men with schizophrenia
description	Takashi Hirata, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Atsushi Kimura, Tadasu Horai, Ichiro Sora Department of Psychiatry, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe, Japan Background: Life expectancy is 10–20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. Materials and methods: The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Results: There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03–1.19]). Conclusion: According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia. Keywords: loss of chromosome Y, schizophrenia, disease duration
format	article
author	Hirata T Hishimoto A Otsuka I Okazaki S Boku S Kimura A Horai T Sora I
author_facet	Hirata T Hishimoto A Otsuka I Okazaki S Boku S Kimura A Horai T Sora I
author_sort	Hirata T
title	Investigation of chromosome Y loss in men with schizophrenia
title_short	Investigation of chromosome Y loss in men with schizophrenia
title_full	Investigation of chromosome Y loss in men with schizophrenia
title_fullStr	Investigation of chromosome Y loss in men with schizophrenia
title_full_unstemmed	Investigation of chromosome Y loss in men with schizophrenia
title_sort	investigation of chromosome y loss in men with schizophrenia
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/05afedf577054a2eadb57245331cd93e
work_keys_str_mv	AT hiratat investigationofchromosomeylossinmenwithschizophrenia AT hishimotoa investigationofchromosomeylossinmenwithschizophrenia AT otsukai investigationofchromosomeylossinmenwithschizophrenia AT okazakis investigationofchromosomeylossinmenwithschizophrenia AT bokus investigationofchromosomeylossinmenwithschizophrenia AT kimuraa investigationofchromosomeylossinmenwithschizophrenia AT horait investigationofchromosomeylossinmenwithschizophrenia AT sorai investigationofchromosomeylossinmenwithschizophrenia
_version_	1718395801208619008

Investigation of chromosome Y loss in men with schizophrenia

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