The genetic regulatory signature of type 2 diabetes in human skeletal muscle
More than 90% of genetic variants associated with type 2 diabetes occur in non-coding regions. Scott et al. report genomes, epigenomes and transcriptomes of skeletal muscle from 271 participants with a range of glucose tolerances, revealing a genetic regulatory architecture enriched in muscle stretc...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/05b203e73f38446db6c6345b6a617738 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:05b203e73f38446db6c6345b6a617738 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:05b203e73f38446db6c6345b6a6177382021-12-02T17:32:05ZThe genetic regulatory signature of type 2 diabetes in human skeletal muscle10.1038/ncomms117642041-1723https://doaj.org/article/05b203e73f38446db6c6345b6a6177382016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11764https://doaj.org/toc/2041-1723More than 90% of genetic variants associated with type 2 diabetes occur in non-coding regions. Scott et al. report genomes, epigenomes and transcriptomes of skeletal muscle from 271 participants with a range of glucose tolerances, revealing a genetic regulatory architecture enriched in muscle stretch/super enhancers.Laura J. ScottMichael R. ErdosJeroen R. HuygheRyan P. WelchAndrew T. BeckBrooke N. WolfordPeter S. ChinesJohn P. DidionNarisu NarisuHeather M. StringhamD. Leland TaylorAnne U. JacksonSwarooparani VadlamudiLori L. BonnycastleLeena KinnunenJouko SaramiesJouko SundvallRicardo D'Oliveira AlbanusAnna KiselevaJohn HensleyGregory E. CrawfordHui JiangXiaoquan WenRichard M. WatanabeTimo A. LakkaKaren L. MohlkeMarkku LaaksoJaakko TuomilehtoHeikki A. KoistinenMichael BoehnkeFrancis S. CollinsStephen C. J. ParkerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Laura J. Scott Michael R. Erdos Jeroen R. Huyghe Ryan P. Welch Andrew T. Beck Brooke N. Wolford Peter S. Chines John P. Didion Narisu Narisu Heather M. Stringham D. Leland Taylor Anne U. Jackson Swarooparani Vadlamudi Lori L. Bonnycastle Leena Kinnunen Jouko Saramies Jouko Sundvall Ricardo D'Oliveira Albanus Anna Kiseleva John Hensley Gregory E. Crawford Hui Jiang Xiaoquan Wen Richard M. Watanabe Timo A. Lakka Karen L. Mohlke Markku Laakso Jaakko Tuomilehto Heikki A. Koistinen Michael Boehnke Francis S. Collins Stephen C. J. Parker The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| description |
More than 90% of genetic variants associated with type 2 diabetes occur in non-coding regions. Scott et al. report genomes, epigenomes and transcriptomes of skeletal muscle from 271 participants with a range of glucose tolerances, revealing a genetic regulatory architecture enriched in muscle stretch/super enhancers. |
| format |
article |
| author |
Laura J. Scott Michael R. Erdos Jeroen R. Huyghe Ryan P. Welch Andrew T. Beck Brooke N. Wolford Peter S. Chines John P. Didion Narisu Narisu Heather M. Stringham D. Leland Taylor Anne U. Jackson Swarooparani Vadlamudi Lori L. Bonnycastle Leena Kinnunen Jouko Saramies Jouko Sundvall Ricardo D'Oliveira Albanus Anna Kiseleva John Hensley Gregory E. Crawford Hui Jiang Xiaoquan Wen Richard M. Watanabe Timo A. Lakka Karen L. Mohlke Markku Laakso Jaakko Tuomilehto Heikki A. Koistinen Michael Boehnke Francis S. Collins Stephen C. J. Parker |
| author_facet |
Laura J. Scott Michael R. Erdos Jeroen R. Huyghe Ryan P. Welch Andrew T. Beck Brooke N. Wolford Peter S. Chines John P. Didion Narisu Narisu Heather M. Stringham D. Leland Taylor Anne U. Jackson Swarooparani Vadlamudi Lori L. Bonnycastle Leena Kinnunen Jouko Saramies Jouko Sundvall Ricardo D'Oliveira Albanus Anna Kiseleva John Hensley Gregory E. Crawford Hui Jiang Xiaoquan Wen Richard M. Watanabe Timo A. Lakka Karen L. Mohlke Markku Laakso Jaakko Tuomilehto Heikki A. Koistinen Michael Boehnke Francis S. Collins Stephen C. J. Parker |
| author_sort |
Laura J. Scott |
| title |
The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| title_short |
The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| title_full |
The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| title_fullStr |
The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| title_full_unstemmed |
The genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| title_sort |
genetic regulatory signature of type 2 diabetes in human skeletal muscle |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/05b203e73f38446db6c6345b6a617738 |
| work_keys_str_mv |
AT laurajscott thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT michaelrerdos thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT jeroenrhuyghe thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT ryanpwelch thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT andrewtbeck thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT brookenwolford thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT peterschines thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT johnpdidion thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT narisunarisu thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT heathermstringham thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT dlelandtaylor thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT anneujackson thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT swarooparanivadlamudi thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT lorilbonnycastle thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT leenakinnunen thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT joukosaramies thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT joukosundvall thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT ricardodoliveiraalbanus thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT annakiseleva thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT johnhensley thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT gregoryecrawford thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT huijiang thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT xiaoquanwen thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT richardmwatanabe thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT timoalakka thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT karenlmohlke thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT markkulaakso thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT jaakkotuomilehto thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT heikkiakoistinen thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT michaelboehnke thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT francisscollins thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT stephencjparker thegeneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT laurajscott geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT michaelrerdos geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT jeroenrhuyghe geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT ryanpwelch geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT andrewtbeck geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT brookenwolford geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT peterschines geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT johnpdidion geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT narisunarisu geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT heathermstringham geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT dlelandtaylor geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT anneujackson geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT swarooparanivadlamudi geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT lorilbonnycastle geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT leenakinnunen geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT joukosaramies geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT joukosundvall geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT ricardodoliveiraalbanus geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT annakiseleva geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT johnhensley geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT gregoryecrawford geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT huijiang geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT xiaoquanwen geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT richardmwatanabe geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT timoalakka geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT karenlmohlke geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT markkulaakso geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT jaakkotuomilehto geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT heikkiakoistinen geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT michaelboehnke geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT francisscollins geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle AT stephencjparker geneticregulatorysignatureoftype2diabetesinhumanskeletalmuscle |
| _version_ |
1718380349076013056 |