Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.

Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invas...

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Autores principales:	Thomas Kalinski, Saadettin Sel, Heiko Hütten, Martin Röpke, Albert Roessner, Norbert Nass
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05b54962a90f4627aa2f736a18e0316f
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spelling	oai:doaj.org-article:05b54962a90f4627aa2f736a18e0316f2021-11-18T08:17:04ZCurcumin blocks interleukin-1 signaling in chondrosarcoma cells.1932-620310.1371/journal.pone.0099296https://doaj.org/article/05b54962a90f4627aa2f736a18e0316f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901233/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required for invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we investigated IL-1β-induced signal transduction and VEGF-A expression in C3842 and SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis assays and NF-κB-related gene expression analyses. Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor. We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further show that Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression. We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.Thomas KalinskiSaadettin SelHeiko HüttenMartin RöpkeAlbert RoessnerNorbert NassPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99296 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Kalinski Saadettin Sel Heiko Hütten Martin Röpke Albert Roessner Norbert Nass Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
description	Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required for invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we investigated IL-1β-induced signal transduction and VEGF-A expression in C3842 and SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis assays and NF-κB-related gene expression analyses. Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor. We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further show that Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression. We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.
format	article
author	Thomas Kalinski Saadettin Sel Heiko Hütten Martin Röpke Albert Roessner Norbert Nass
author_facet	Thomas Kalinski Saadettin Sel Heiko Hütten Martin Röpke Albert Roessner Norbert Nass
author_sort	Thomas Kalinski
title	Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
title_short	Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
title_full	Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
title_fullStr	Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
title_full_unstemmed	Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
title_sort	curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/05b54962a90f4627aa2f736a18e0316f
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Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.

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