Pressure modulates the self-cleavage step of the hairpin ribozyme

Studying the reactivity of ribozymes under extreme pressure could provide insights to optimize biocatalytic RNA design. Here, the authors show that at high pressure the transesterification step of the hairpin ribozyme self-cleavage reaction accelerates, while the overall process is slower.

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Autores principales: Caroline Schuabb, Narendra Kumar, Salome Pataraia, Dominik Marx, Roland Winter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/05b58b73a1014bc7b73aa2c2168b3b62
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