DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE

Objective: To characterize the clinical presentations and laboratory markers (as disease predictors and markers) and severity of disease in patients admitted with dengue fever. Study Design: Prospective observational study. Place and Duration of Study: Department of Infectious Diseases, Pak Em...

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Autores principales:	Taimoor Ashraf Khan, Shazia Nisar, Muhammad Mahad Qureshi, Muhammad Samiullah, Muhammad Israr
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	alanine aminotransferase alkaline phosphatase dengue fever dengue hemorrhagic fever liver enzymes Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/05b6069ca6114e599e1894bbcc4d0216
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spelling	oai:doaj.org-article:05b6069ca6114e599e1894bbcc4d02162021-11-18T02:52:23ZDENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE0030-96482411-8842https://doaj.org/article/05b6069ca6114e599e1894bbcc4d02162021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/4165/3565https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To characterize the clinical presentations and laboratory markers (as disease predictors and markers) and severity of disease in patients admitted with dengue fever. Study Design: Prospective observational study. Place and Duration of Study: Department of Infectious Diseases, Pak Emirates Military Hospital Rawalpindi, from May to Oct 2018 Methodology: In our study, we included the patients treated for dengue fever. Data were recorded on predesigned proforma and analyzed using Microsoft excel 365 and Social Package for Statistical Sciences version 23. Results: A total of 160 patients were included in this study, all were males. All cases were positive for Nonstructural Protein 1 Antigen. Symptoms seen in abundance were fever with rigors, chills, backache, retro-orbital pain, nausea and vomiting. Manual platelet count at admission ranged from 15-396 x 103 (mean 107.5 ± 6.8 x 103). Platelet count on discharge ranged from 102-577 x 103 (mean 207.9 ± 95.4 x 103). A total of 34 (21.25%) patients out of 160 confirmed and admitted dengue fever cases had Dengue Hemorrhagic Fever (Nonstructural Protein 1 Antigen positive, thrombocytopenia and leukopenia) and 2 patient went into dengue shock syndrome. The derangement in alanine aminotransferase and alkaline phosphatase levels were shown in 98 (61.2%) and 62 (31.2%) of patients. All these patients were immunoglobulin M and Nonstructural Protein 1 Antigen positive. Conclusion: Raised serum alanine aminotransferase and alkaline phosphatase levels along with early positive Nonstructural Protein 1 Antigen is a marker of disease severity.Taimoor Ashraf KhanShazia NisarMuhammad Mahad QureshiMuhammad SamiullahMuhammad IsrarArmy Medical College Rawalpindiarticlealanine aminotransferasealkaline phosphatasedengue feverdengue hemorrhagic feverliver enzymesMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1524-1528 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alanine aminotransferase alkaline phosphatase dengue fever dengue hemorrhagic fever liver enzymes Medicine R Medicine (General) R5-920
spellingShingle	alanine aminotransferase alkaline phosphatase dengue fever dengue hemorrhagic fever liver enzymes Medicine R Medicine (General) R5-920 Taimoor Ashraf Khan Shazia Nisar Muhammad Mahad Qureshi Muhammad Samiullah Muhammad Israr DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE
description	Objective: To characterize the clinical presentations and laboratory markers (as disease predictors and markers) and severity of disease in patients admitted with dengue fever. Study Design: Prospective observational study. Place and Duration of Study: Department of Infectious Diseases, Pak Emirates Military Hospital Rawalpindi, from May to Oct 2018 Methodology: In our study, we included the patients treated for dengue fever. Data were recorded on predesigned proforma and analyzed using Microsoft excel 365 and Social Package for Statistical Sciences version 23. Results: A total of 160 patients were included in this study, all were males. All cases were positive for Nonstructural Protein 1 Antigen. Symptoms seen in abundance were fever with rigors, chills, backache, retro-orbital pain, nausea and vomiting. Manual platelet count at admission ranged from 15-396 x 103 (mean 107.5 ± 6.8 x 103). Platelet count on discharge ranged from 102-577 x 103 (mean 207.9 ± 95.4 x 103). A total of 34 (21.25%) patients out of 160 confirmed and admitted dengue fever cases had Dengue Hemorrhagic Fever (Nonstructural Protein 1 Antigen positive, thrombocytopenia and leukopenia) and 2 patient went into dengue shock syndrome. The derangement in alanine aminotransferase and alkaline phosphatase levels were shown in 98 (61.2%) and 62 (31.2%) of patients. All these patients were immunoglobulin M and Nonstructural Protein 1 Antigen positive. Conclusion: Raised serum alanine aminotransferase and alkaline phosphatase levels along with early positive Nonstructural Protein 1 Antigen is a marker of disease severity.
format	article
author	Taimoor Ashraf Khan Shazia Nisar Muhammad Mahad Qureshi Muhammad Samiullah Muhammad Israr
author_facet	Taimoor Ashraf Khan Shazia Nisar Muhammad Mahad Qureshi Muhammad Samiullah Muhammad Israr
author_sort	Taimoor Ashraf Khan
title	DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE
title_short	DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE
title_full	DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE
title_fullStr	DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE
title_full_unstemmed	DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE
title_sort	dengue fever outbreak in twin cities; a tertiary care center experience
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/05b6069ca6114e599e1894bbcc4d0216
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DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE

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