Truncating tau reveals different pathophysiological actions of oligomers in single neurons

Hill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration...

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Autores principales:	Emily Hill, Thomas K. Karikari, Juan Lantero-Rodriguez, Henrik Zetterberg, Kaj Blennow, Magnus J. Richardson, Mark J. Wall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/05b64a0a00e849388b47bc3893ecef99
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spelling	oai:doaj.org-article:05b64a0a00e849388b47bc3893ecef992021-11-07T12:19:48ZTruncating tau reveals different pathophysiological actions of oligomers in single neurons10.1038/s42003-021-02791-x2399-3642https://doaj.org/article/05b64a0a00e849388b47bc3893ecef992021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02791-xhttps://doaj.org/toc/2399-3642Hill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration in voltage-gated sodium channel currents.Emily HillThomas K. KarikariJuan Lantero-RodriguezHenrik ZetterbergKaj BlennowMagnus J. RichardsonMark J. WallNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Emily Hill Thomas K. Karikari Juan Lantero-Rodriguez Henrik Zetterberg Kaj Blennow Magnus J. Richardson Mark J. Wall Truncating tau reveals different pathophysiological actions of oligomers in single neurons
description	Hill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration in voltage-gated sodium channel currents.
format	article
author	Emily Hill Thomas K. Karikari Juan Lantero-Rodriguez Henrik Zetterberg Kaj Blennow Magnus J. Richardson Mark J. Wall
author_facet	Emily Hill Thomas K. Karikari Juan Lantero-Rodriguez Henrik Zetterberg Kaj Blennow Magnus J. Richardson Mark J. Wall
author_sort	Emily Hill
title	Truncating tau reveals different pathophysiological actions of oligomers in single neurons
title_short	Truncating tau reveals different pathophysiological actions of oligomers in single neurons
title_full	Truncating tau reveals different pathophysiological actions of oligomers in single neurons
title_fullStr	Truncating tau reveals different pathophysiological actions of oligomers in single neurons
title_full_unstemmed	Truncating tau reveals different pathophysiological actions of oligomers in single neurons
title_sort	truncating tau reveals different pathophysiological actions of oligomers in single neurons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05b64a0a00e849388b47bc3893ecef99
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Truncating tau reveals different pathophysiological actions of oligomers in single neurons

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