Truncating tau reveals different pathophysiological actions of oligomers in single neurons

Hill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration...

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Auteurs principaux: Emily Hill, Thomas K. Karikari, Juan Lantero-Rodriguez, Henrik Zetterberg, Kaj Blennow, Magnus J. Richardson, Mark J. Wall
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/05b64a0a00e849388b47bc3893ecef99
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