Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active and, thus, may have phenotypic consequences.

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Autores principales:	Henrik Devitt Møller, Marghoob Mohiyuddin, Iñigo Prada-Luengo, M. Reza Sailani, Jens Frey Halling, Peter Plomgaard, Lasse Maretty, Anders Johannes Hansen, Michael P. Snyder, Henriette Pilegaard, Hugo Y. K. Lam, Birgitte Regenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05b697de38844d63ad7af833e2a47a93
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spelling	oai:doaj.org-article:05b697de38844d63ad7af833e2a47a932021-12-02T16:56:40ZCircular DNA elements of chromosomal origin are common in healthy human somatic tissue10.1038/s41467-018-03369-82041-1723https://doaj.org/article/05b697de38844d63ad7af833e2a47a932018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03369-8https://doaj.org/toc/2041-1723Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active and, thus, may have phenotypic consequences.Henrik Devitt MøllerMarghoob MohiyuddinIñigo Prada-LuengoM. Reza SailaniJens Frey HallingPeter PlomgaardLasse MarettyAnders Johannes HansenMichael P. SnyderHenriette PilegaardHugo Y. K. LamBirgitte RegenbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Henrik Devitt Møller Marghoob Mohiyuddin Iñigo Prada-Luengo M. Reza Sailani Jens Frey Halling Peter Plomgaard Lasse Maretty Anders Johannes Hansen Michael P. Snyder Henriette Pilegaard Hugo Y. K. Lam Birgitte Regenberg Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
description	Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active and, thus, may have phenotypic consequences.
format	article
author	Henrik Devitt Møller Marghoob Mohiyuddin Iñigo Prada-Luengo M. Reza Sailani Jens Frey Halling Peter Plomgaard Lasse Maretty Anders Johannes Hansen Michael P. Snyder Henriette Pilegaard Hugo Y. K. Lam Birgitte Regenberg
author_facet	Henrik Devitt Møller Marghoob Mohiyuddin Iñigo Prada-Luengo M. Reza Sailani Jens Frey Halling Peter Plomgaard Lasse Maretty Anders Johannes Hansen Michael P. Snyder Henriette Pilegaard Hugo Y. K. Lam Birgitte Regenberg
author_sort	Henrik Devitt Møller
title	Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
title_short	Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
title_full	Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
title_fullStr	Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
title_full_unstemmed	Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
title_sort	circular dna elements of chromosomal origin are common in healthy human somatic tissue
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/05b697de38844d63ad7af833e2a47a93
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Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

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