SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE

Abstract. In present work, we studied some interrelations between tobacco smoking and the processes of immune system stimulation in healthy blood donors. In our opinion, this issue is especially important for the big industrial center, with rather strong antigenic exposure of the organism. The level...

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Autores principales:	O. O. Obukhova, A. N. Trunov, O. M. Gorbenko, A. P. Shvajuk, A. V. Obukhov, S. M. Chornaja
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunity smoking healthy donors immune complexes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/05b967e8545945b197025f09de8811b9
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spelling	oai:doaj.org-article:05b967e8545945b197025f09de8811b92021-11-18T08:03:41ZSOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE1563-06252313-741X10.15789/1563-0625-2006-1-91-96https://doaj.org/article/05b967e8545945b197025f09de8811b92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/447https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In present work, we studied some interrelations between tobacco smoking and the processes of immune system stimulation in healthy blood donors. In our opinion, this issue is especially important for the big industrial center, with rather strong antigenic exposure of the organism. The levels of circulating immune complexes (CIC) were used as a marker index which reflects specific antigen-antibody interactions during inflammation. According to the results obtained, the majority of persons who have high CIC levels were tobacco smokers (53.76%). Moreover, the percentage of persons with high CIC content, like as the mean values of this index is increased proportionally to the duration of smoking. A mixture of tobacco smoke components seems to exert direct toxic effect upon various compartments of the immune system and causes local irritation of bronchial tree, thus producing local and systemic inflammatory reaction. It is, possibly, an additional factor which determines activation of immune system, with a background of adverse antropogenic exposures typical to industrial centers. The data obtained allow us to affirm a toxic action of tobacco smoke upon the organism of smokers, with development of inflammatory reactions that are displayed as increased CIC levels at preclinical stage.O. O. ObukhovaA. N. TrunovO. M. GorbenkoA. P. ShvajukA. V. ObukhovS. M. ChornajaSPb RAACIarticleimmunitysmokinghealthy donorsimmune complexesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 1, Pp 91-96 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity smoking healthy donors immune complexes Immunologic diseases. Allergy RC581-607
spellingShingle	immunity smoking healthy donors immune complexes Immunologic diseases. Allergy RC581-607 O. O. Obukhova A. N. Trunov O. M. Gorbenko A. P. Shvajuk A. V. Obukhov S. M. Chornaja SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
description	Abstract. In present work, we studied some interrelations between tobacco smoking and the processes of immune system stimulation in healthy blood donors. In our opinion, this issue is especially important for the big industrial center, with rather strong antigenic exposure of the organism. The levels of circulating immune complexes (CIC) were used as a marker index which reflects specific antigen-antibody interactions during inflammation. According to the results obtained, the majority of persons who have high CIC levels were tobacco smokers (53.76%). Moreover, the percentage of persons with high CIC content, like as the mean values of this index is increased proportionally to the duration of smoking. A mixture of tobacco smoke components seems to exert direct toxic effect upon various compartments of the immune system and causes local irritation of bronchial tree, thus producing local and systemic inflammatory reaction. It is, possibly, an additional factor which determines activation of immune system, with a background of adverse antropogenic exposures typical to industrial centers. The data obtained allow us to affirm a toxic action of tobacco smoke upon the organism of smokers, with development of inflammatory reactions that are displayed as increased CIC levels at preclinical stage.
format	article
author	O. O. Obukhova A. N. Trunov O. M. Gorbenko A. P. Shvajuk A. V. Obukhov S. M. Chornaja
author_facet	O. O. Obukhova A. N. Trunov O. M. Gorbenko A. P. Shvajuk A. V. Obukhov S. M. Chornaja
author_sort	O. O. Obukhova
title	SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
title_short	SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
title_full	SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
title_fullStr	SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
title_full_unstemmed	SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
title_sort	some aspects of immune system functioning in healthy donors subjected to xenogenous exposure
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/05b967e8545945b197025f09de8811b9
work_keys_str_mv	AT ooobukhova someaspectsofimmunesystemfunctioninginhealthydonorssubjectedtoxenogenousexposure AT antrunov someaspectsofimmunesystemfunctioninginhealthydonorssubjectedtoxenogenousexposure AT omgorbenko someaspectsofimmunesystemfunctioninginhealthydonorssubjectedtoxenogenousexposure AT apshvajuk someaspectsofimmunesystemfunctioninginhealthydonorssubjectedtoxenogenousexposure AT avobukhov someaspectsofimmunesystemfunctioninginhealthydonorssubjectedtoxenogenousexposure AT smchornaja someaspectsofimmunesystemfunctioninginhealthydonorssubjectedtoxenogenousexposure
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SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE

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