Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp2-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/05bc5ed38fd947ddaae9f97a533c0aca |
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| Sumario: | Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp2-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation of benzocyclobutenones and their coupling with pedant dienamides. |
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