Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition

Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp2-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation...

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Autores principales:	Jianyu Zhang, Xi Wang, Tao Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05bc5ed38fd947ddaae9f97a533c0aca
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id	oai:doaj.org-article:05bc5ed38fd947ddaae9f97a533c0aca
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spelling	oai:doaj.org-article:05bc5ed38fd947ddaae9f97a533c0aca2021-12-02T14:58:43ZRegioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition10.1038/s41467-021-23344-02041-1723https://doaj.org/article/05bc5ed38fd947ddaae9f97a533c0aca2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23344-0https://doaj.org/toc/2041-1723Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp2-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation of benzocyclobutenones and their coupling with pedant dienamides.Jianyu ZhangXi WangTao XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianyu Zhang Xi Wang Tao Xu Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
description	Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp2-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation of benzocyclobutenones and their coupling with pedant dienamides.
format	article
author	Jianyu Zhang Xi Wang Tao Xu
author_facet	Jianyu Zhang Xi Wang Tao Xu
author_sort	Jianyu Zhang
title	Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
title_short	Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
title_full	Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
title_fullStr	Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
title_full_unstemmed	Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
title_sort	regioselective activation of benzocyclobutenones and dienamides lead to anti-bredt bridged-ring systems by a [4+4] cycloaddition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05bc5ed38fd947ddaae9f97a533c0aca
work_keys_str_mv	AT jianyuzhang regioselectiveactivationofbenzocyclobutenonesanddienamidesleadtoantibredtbridgedringsystemsbya44cycloaddition AT xiwang regioselectiveactivationofbenzocyclobutenonesanddienamidesleadtoantibredtbridgedringsystemsbya44cycloaddition AT taoxu regioselectiveactivationofbenzocyclobutenonesanddienamidesleadtoantibredtbridgedringsystemsbya44cycloaddition
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Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition

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