The rates of stem cell division determine the cell cycle lengths of its lineage

Summary: Adult stem cells and their transit-amplifying progeny alter their proliferation rates to maintain tissue homeostasis. To test how the division rates of stem cells and transit-amplifying progeny affect tissue growth and differentiation, we developed a computation strategy that estimates the...

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Autores principales:	Purna Gadre, Nitin Nitsure, Debasmita Mazumdar, Samir Gupta, Krishanu Ray
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cell biology Stem cells research Bioinformatics Science Q
Acceso en línea:	https://doaj.org/article/05c054e2ee5f4fadb881d5684add8be1
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spelling	oai:doaj.org-article:05c054e2ee5f4fadb881d5684add8be12021-11-20T05:08:36ZThe rates of stem cell division determine the cell cycle lengths of its lineage2589-004210.1016/j.isci.2021.103232https://doaj.org/article/05c054e2ee5f4fadb881d5684add8be12021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012001https://doaj.org/toc/2589-0042Summary: Adult stem cells and their transit-amplifying progeny alter their proliferation rates to maintain tissue homeostasis. To test how the division rates of stem cells and transit-amplifying progeny affect tissue growth and differentiation, we developed a computation strategy that estimates the average cell-cycle lengths (lifespans) of germline stem cells and their progeny from fixed-tissue demography in the Drosophila testis. Analysis of the wild-type data using this method indicated that during the germline transit-amplification, the cellular lifespans extend by nearly 1.3-fold after the first division and shrink by about 2-folds after the second division. Cell-autonomous perturbations of the stem cell lifespan accordingly altered the lifespans of successive transit-amplifying stages. Remarkably, almost 2-fold alterations in the lifespans of stem cells and their immediate daughters did not affect the subsequent differentiation. The results indicate that the early germline division rates can adjust the following division rates and the onset of differentiation.Purna GadreNitin NitsureDebasmita MazumdarSamir GuptaKrishanu RayElsevierarticleCell biologyStem cells researchBioinformaticsScienceQENiScience, Vol 24, Iss 11, Pp 103232- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell biology Stem cells research Bioinformatics Science Q
spellingShingle	Cell biology Stem cells research Bioinformatics Science Q Purna Gadre Nitin Nitsure Debasmita Mazumdar Samir Gupta Krishanu Ray The rates of stem cell division determine the cell cycle lengths of its lineage
description	Summary: Adult stem cells and their transit-amplifying progeny alter their proliferation rates to maintain tissue homeostasis. To test how the division rates of stem cells and transit-amplifying progeny affect tissue growth and differentiation, we developed a computation strategy that estimates the average cell-cycle lengths (lifespans) of germline stem cells and their progeny from fixed-tissue demography in the Drosophila testis. Analysis of the wild-type data using this method indicated that during the germline transit-amplification, the cellular lifespans extend by nearly 1.3-fold after the first division and shrink by about 2-folds after the second division. Cell-autonomous perturbations of the stem cell lifespan accordingly altered the lifespans of successive transit-amplifying stages. Remarkably, almost 2-fold alterations in the lifespans of stem cells and their immediate daughters did not affect the subsequent differentiation. The results indicate that the early germline division rates can adjust the following division rates and the onset of differentiation.
format	article
author	Purna Gadre Nitin Nitsure Debasmita Mazumdar Samir Gupta Krishanu Ray
author_facet	Purna Gadre Nitin Nitsure Debasmita Mazumdar Samir Gupta Krishanu Ray
author_sort	Purna Gadre
title	The rates of stem cell division determine the cell cycle lengths of its lineage
title_short	The rates of stem cell division determine the cell cycle lengths of its lineage
title_full	The rates of stem cell division determine the cell cycle lengths of its lineage
title_fullStr	The rates of stem cell division determine the cell cycle lengths of its lineage
title_full_unstemmed	The rates of stem cell division determine the cell cycle lengths of its lineage
title_sort	rates of stem cell division determine the cell cycle lengths of its lineage
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/05c054e2ee5f4fadb881d5684add8be1
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The rates of stem cell division determine the cell cycle lengths of its lineage

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