The ABC of Ribosome-Related Antibiotic Resistance
ABSTRACT The increase in multidrug-resistant pathogenic bacteria is limiting the utility of our current arsenal of antimicrobial agents. Mechanistically understanding how bacteria obtain antibiotic resistance is a critical first step to the development of improved inhibitors. One common mechanism fo...
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American Society for Microbiology
2016
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oai:doaj.org-article:05c39c7185b34d0a92156f83ca91d1ee2021-11-15T15:50:17ZThe ABC of Ribosome-Related Antibiotic Resistance10.1128/mBio.00598-162150-7511https://doaj.org/article/05c39c7185b34d0a92156f83ca91d1ee2016-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00598-16https://doaj.org/toc/2150-7511ABSTRACT The increase in multidrug-resistant pathogenic bacteria is limiting the utility of our current arsenal of antimicrobial agents. Mechanistically understanding how bacteria obtain antibiotic resistance is a critical first step to the development of improved inhibitors. One common mechanism for bacteria to obtain antibiotic resistance is by employing ATP-binding cassette (ABC) transporters to actively pump the drug from the cell. The ABC-F family includes proteins conferring resistance to a variety of clinically important ribosome-targeting antibiotics; however, controversy remains as to whether resistance is conferred via efflux like other ABC transporters or whether another mechanism, such as ribosome protection, is at play. A recent study by Sharkey and coworkers (L. K. Sharkey, T. A. Edwards, and A. J. O’Neill, mBio 7:e01975-15, 2016, http://dx.doi.org/10.1128/mBio.01975-15) provides strong evidence that ABC-F proteins conferring antibiotic resistance utilize ribosome protection mechanisms, namely, by interacting with the ribosome and displacing the drug from its binding site, thus revealing a novel role for ABC-F proteins in antibiotic resistance.Daniel N. WilsonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 3 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Microbiology QR1-502 |
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Microbiology QR1-502 Daniel N. Wilson The ABC of Ribosome-Related Antibiotic Resistance |
| description |
ABSTRACT The increase in multidrug-resistant pathogenic bacteria is limiting the utility of our current arsenal of antimicrobial agents. Mechanistically understanding how bacteria obtain antibiotic resistance is a critical first step to the development of improved inhibitors. One common mechanism for bacteria to obtain antibiotic resistance is by employing ATP-binding cassette (ABC) transporters to actively pump the drug from the cell. The ABC-F family includes proteins conferring resistance to a variety of clinically important ribosome-targeting antibiotics; however, controversy remains as to whether resistance is conferred via efflux like other ABC transporters or whether another mechanism, such as ribosome protection, is at play. A recent study by Sharkey and coworkers (L. K. Sharkey, T. A. Edwards, and A. J. O’Neill, mBio 7:e01975-15, 2016, http://dx.doi.org/10.1128/mBio.01975-15) provides strong evidence that ABC-F proteins conferring antibiotic resistance utilize ribosome protection mechanisms, namely, by interacting with the ribosome and displacing the drug from its binding site, thus revealing a novel role for ABC-F proteins in antibiotic resistance. |
| format |
article |
| author |
Daniel N. Wilson |
| author_facet |
Daniel N. Wilson |
| author_sort |
Daniel N. Wilson |
| title |
The ABC of Ribosome-Related Antibiotic Resistance |
| title_short |
The ABC of Ribosome-Related Antibiotic Resistance |
| title_full |
The ABC of Ribosome-Related Antibiotic Resistance |
| title_fullStr |
The ABC of Ribosome-Related Antibiotic Resistance |
| title_full_unstemmed |
The ABC of Ribosome-Related Antibiotic Resistance |
| title_sort |
abc of ribosome-related antibiotic resistance |
| publisher |
American Society for Microbiology |
| publishDate |
2016 |
| url |
https://doaj.org/article/05c39c7185b34d0a92156f83ca91d1ee |
| work_keys_str_mv |
AT danielnwilson theabcofribosomerelatedantibioticresistance AT danielnwilson abcofribosomerelatedantibioticresistance |
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1718427379007750144 |