Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy

Abstract Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and...

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Autores principales:	Selvin Z. Reyes-Garcia, Carla A. Scorza, Noemi S. Araújo, Nancy N. Ortiz-Villatoro, Anaclara Prada Jardim, Ricardo Centeno, Elza Márcia Targas Yacubian, Jean Faber, Esper A. Cavalheiro
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Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05c76537cf6e4658bfd405a87285b0b6
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spelling	oai:doaj.org-article:05c76537cf6e4658bfd405a87285b0b62021-12-02T11:41:23ZDifferent patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy10.1038/s41598-018-25378-92045-2322https://doaj.org/article/05c76537cf6e4658bfd405a87285b0b62018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25378-9https://doaj.org/toc/2045-2322Abstract Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE. Five types of epileptiform-like activity were observed: interictal-like events; periodic ictal spiking; seizure-like events; spreading depression-like events; tonic seizure-like events and no activity. Different susceptibilities to generate epileptiform activity among hippocampal regions were observed; the dentate gyrus was the most susceptible region followed by the subiculum, CA4, CA1, CA2 and CA3. The incidence of epileptiform activity pattern was associated with specific regions of the hippocampal formation. Moreover, it was observed that each region of the hippocampal formation exhibits frequency-specific ranges in each subfield of the sclerotic human tissue. In conclusion, this study demonstrates that epileptiform-like activity may be induced in different regions of the hippocampal formation, including regions that are severely affected by neuronal loss.Selvin Z. Reyes-GarciaCarla A. ScorzaNoemi S. AraújoNancy N. Ortiz-VillatoroAnaclara Prada JardimRicardo CentenoElza Márcia Targas YacubianJean FaberEsper A. CavalheiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Selvin Z. Reyes-Garcia Carla A. Scorza Noemi S. Araújo Nancy N. Ortiz-Villatoro Anaclara Prada Jardim Ricardo Centeno Elza Márcia Targas Yacubian Jean Faber Esper A. Cavalheiro Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
description	Abstract Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE. Five types of epileptiform-like activity were observed: interictal-like events; periodic ictal spiking; seizure-like events; spreading depression-like events; tonic seizure-like events and no activity. Different susceptibilities to generate epileptiform activity among hippocampal regions were observed; the dentate gyrus was the most susceptible region followed by the subiculum, CA4, CA1, CA2 and CA3. The incidence of epileptiform activity pattern was associated with specific regions of the hippocampal formation. Moreover, it was observed that each region of the hippocampal formation exhibits frequency-specific ranges in each subfield of the sclerotic human tissue. In conclusion, this study demonstrates that epileptiform-like activity may be induced in different regions of the hippocampal formation, including regions that are severely affected by neuronal loss.
format	article
author	Selvin Z. Reyes-Garcia Carla A. Scorza Noemi S. Araújo Nancy N. Ortiz-Villatoro Anaclara Prada Jardim Ricardo Centeno Elza Márcia Targas Yacubian Jean Faber Esper A. Cavalheiro
author_facet	Selvin Z. Reyes-Garcia Carla A. Scorza Noemi S. Araújo Nancy N. Ortiz-Villatoro Anaclara Prada Jardim Ricardo Centeno Elza Márcia Targas Yacubian Jean Faber Esper A. Cavalheiro
author_sort	Selvin Z. Reyes-Garcia
title	Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
title_short	Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
title_full	Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
title_fullStr	Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
title_full_unstemmed	Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
title_sort	different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/05c76537cf6e4658bfd405a87285b0b6
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Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy

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