H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma pat...

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Main Authors: Kolja Schleich, Julia Kase, Jan R. Dörr, Saskia Trescher, Animesh Bhattacharya, Yong Yu, Elizabeth M. Wailes, Dorothy N. Y. Fan, Philipp Lohneis, Maja Milanovic, Andrea Lau, Dido Lenze, Michael Hummel, Bjoern Chapuy, Ulf Leser, Maurice Reimann, Soyoung Lee, Clemens A. Schmitt
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/05c76f30d3fb41ad9a1c454ca0327848
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Summary:Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.

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