H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma pat...

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Autores principales:	Kolja Schleich, Julia Kase, Jan R. Dörr, Saskia Trescher, Animesh Bhattacharya, Yong Yu, Elizabeth M. Wailes, Dorothy N. Y. Fan, Philipp Lohneis, Maja Milanovic, Andrea Lau, Dido Lenze, Michael Hummel, Bjoern Chapuy, Ulf Leser, Maurice Reimann, Soyoung Lee, Clemens A. Schmitt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05c76f30d3fb41ad9a1c454ca0327848
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spelling	oai:doaj.org-article:05c76f30d3fb41ad9a1c454ca03278482021-12-02T17:55:10ZH3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients10.1038/s41467-020-17467-z2041-1723https://doaj.org/article/05c76f30d3fb41ad9a1c454ca03278482020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17467-zhttps://doaj.org/toc/2041-1723Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.Kolja SchleichJulia KaseJan R. DörrSaskia TrescherAnimesh BhattacharyaYong YuElizabeth M. WailesDorothy N. Y. FanPhilipp LohneisMaja MilanovicAndrea LauDido LenzeMichael HummelBjoern ChapuyUlf LeserMaurice ReimannSoyoung LeeClemens A. SchmittNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kolja Schleich Julia Kase Jan R. Dörr Saskia Trescher Animesh Bhattacharya Yong Yu Elizabeth M. Wailes Dorothy N. Y. Fan Philipp Lohneis Maja Milanovic Andrea Lau Dido Lenze Michael Hummel Bjoern Chapuy Ulf Leser Maurice Reimann Soyoung Lee Clemens A. Schmitt H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
description	Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.
format	article
author	Kolja Schleich Julia Kase Jan R. Dörr Saskia Trescher Animesh Bhattacharya Yong Yu Elizabeth M. Wailes Dorothy N. Y. Fan Philipp Lohneis Maja Milanovic Andrea Lau Dido Lenze Michael Hummel Bjoern Chapuy Ulf Leser Maurice Reimann Soyoung Lee Clemens A. Schmitt
author_facet	Kolja Schleich Julia Kase Jan R. Dörr Saskia Trescher Animesh Bhattacharya Yong Yu Elizabeth M. Wailes Dorothy N. Y. Fan Philipp Lohneis Maja Milanovic Andrea Lau Dido Lenze Michael Hummel Bjoern Chapuy Ulf Leser Maurice Reimann Soyoung Lee Clemens A. Schmitt
author_sort	Kolja Schleich
title	H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_short	H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_full	H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_fullStr	H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_full_unstemmed	H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_sort	h3k9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/05c76f30d3fb41ad9a1c454ca0327848
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H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

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