H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma pat...

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Autores principales: Kolja Schleich, Julia Kase, Jan R. Dörr, Saskia Trescher, Animesh Bhattacharya, Yong Yu, Elizabeth M. Wailes, Dorothy N. Y. Fan, Philipp Lohneis, Maja Milanovic, Andrea Lau, Dido Lenze, Michael Hummel, Bjoern Chapuy, Ulf Leser, Maurice Reimann, Soyoung Lee, Clemens A. Schmitt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/05c76f30d3fb41ad9a1c454ca0327848
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