Mediated nuclear import and export of TAZ and the underlying molecular requirements

Mediated nuclear import and export of TAZ and the underlying molecular requirements

The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal nuclear export signal of TAZ in an epithelial ce...

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Autores principales: Michael Kofler, Pam Speight, Darby Little, Caterina Di Ciano-Oliveira, Katalin Szászi, András Kapus
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/05c809265a8e415ca20e418896691dcc
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spelling oai:doaj.org-article:05c809265a8e415ca20e418896691dcc2021-12-02T16:49:35ZMediated nuclear import and export of TAZ and the underlying molecular requirements10.1038/s41467-018-07450-02041-1723https://doaj.org/article/05c809265a8e415ca20e418896691dcc2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07450-0https://doaj.org/toc/2041-1723The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal nuclear export signal of TAZ in an epithelial cell line.Michael KoflerPam SpeightDarby LittleCaterina Di Ciano-OliveiraKatalin SzásziAndrás KapusNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michael Kofler
Pam Speight
Darby Little
Caterina Di Ciano-Oliveira
Katalin Szászi
András Kapus
Mediated nuclear import and export of TAZ and the underlying molecular requirements
description The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal nuclear export signal of TAZ in an epithelial cell line.
format article
author Michael Kofler
Pam Speight
Darby Little
Caterina Di Ciano-Oliveira
Katalin Szászi
András Kapus
author_facet Michael Kofler
Pam Speight
Darby Little
Caterina Di Ciano-Oliveira
Katalin Szászi
András Kapus
author_sort Michael Kofler
title Mediated nuclear import and export of TAZ and the underlying molecular requirements
title_short Mediated nuclear import and export of TAZ and the underlying molecular requirements
title_full Mediated nuclear import and export of TAZ and the underlying molecular requirements
title_fullStr Mediated nuclear import and export of TAZ and the underlying molecular requirements
title_full_unstemmed Mediated nuclear import and export of TAZ and the underlying molecular requirements
title_sort mediated nuclear import and export of taz and the underlying molecular requirements
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/05c809265a8e415ca20e418896691dcc
work_keys_str_mv AT michaelkofler mediatednuclearimportandexportoftazandtheunderlyingmolecularrequirements
AT pamspeight mediatednuclearimportandexportoftazandtheunderlyingmolecularrequirements
AT darbylittle mediatednuclearimportandexportoftazandtheunderlyingmolecularrequirements
AT caterinadicianooliveira mediatednuclearimportandexportoftazandtheunderlyingmolecularrequirements
AT katalinszaszi mediatednuclearimportandexportoftazandtheunderlyingmolecularrequirements
AT andraskapus mediatednuclearimportandexportoftazandtheunderlyingmolecularrequirements
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