Zoopharmacognosy in diseased laboratory mice: conflicting evidence.

Zoopharmacognosy denotes a constellation of learned ingestive responses that promote healing and survival of infected or poisoned animals. A similar self-medication phenomenon was reported in diseased laboratory rodents. In particular, a series of studies revealed that autoimmune MRL/lpr mice readil...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Minesh Kapadia, Hui Zhao, Donglai Ma, Rupal Hatkar, Monica Marchese, Boris Sakic
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05c958b61c764af4b740505bd29600f4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:05c958b61c764af4b740505bd29600f4
record_format	dspace
spelling	oai:doaj.org-article:05c958b61c764af4b740505bd29600f42021-11-11T08:21:57ZZoopharmacognosy in diseased laboratory mice: conflicting evidence.1932-620310.1371/journal.pone.0100684https://doaj.org/article/05c958b61c764af4b740505bd29600f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24956477/?tool=EBIhttps://doaj.org/toc/1932-6203Zoopharmacognosy denotes a constellation of learned ingestive responses that promote healing and survival of infected or poisoned animals. A similar self-medication phenomenon was reported in diseased laboratory rodents. In particular, a series of studies revealed that autoimmune MRL/lpr mice readily consume solutions paired or laced with cyclophosphamide (CY), an immunosuppressive drug that prevents inflammatory damage to internal organs. However, due to design limitations, it could not be elucidated whether such a response reflects the learned therapeutic effect of CY, or a deficit in sensory input. We presently assess the behavioural effects of prolonged consumption of CY-laced, 16% sucrose solution in a continuous choice paradigm, with tap water available ad lib. Contrary to overall expectation, MRL/lpr mice did not increase their intake of CY with disease progression. Moreover, they ingested lower doses of CY and preferred less CY-laced sucrose solution than age-matched controls. The results obtained could not confirm zoopharmacognosy in diseased MRL/lpr mice, likely due to impaired responsiveness to palatable stimulation, or attenuated survival mechanisms after prolonged inbreeding in captivity. However, by revealing the effectiveness of unrestricted drinking of drug-laced sucrose solution on behavior and immunity, the current study supports broader use of such an administration route in behavioural studies sensitive to external stressors.Minesh KapadiaHui ZhaoDonglai MaRupal HatkarMonica MarcheseBoris SakicPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100684 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minesh Kapadia Hui Zhao Donglai Ma Rupal Hatkar Monica Marchese Boris Sakic Zoopharmacognosy in diseased laboratory mice: conflicting evidence.
description	Zoopharmacognosy denotes a constellation of learned ingestive responses that promote healing and survival of infected or poisoned animals. A similar self-medication phenomenon was reported in diseased laboratory rodents. In particular, a series of studies revealed that autoimmune MRL/lpr mice readily consume solutions paired or laced with cyclophosphamide (CY), an immunosuppressive drug that prevents inflammatory damage to internal organs. However, due to design limitations, it could not be elucidated whether such a response reflects the learned therapeutic effect of CY, or a deficit in sensory input. We presently assess the behavioural effects of prolonged consumption of CY-laced, 16% sucrose solution in a continuous choice paradigm, with tap water available ad lib. Contrary to overall expectation, MRL/lpr mice did not increase their intake of CY with disease progression. Moreover, they ingested lower doses of CY and preferred less CY-laced sucrose solution than age-matched controls. The results obtained could not confirm zoopharmacognosy in diseased MRL/lpr mice, likely due to impaired responsiveness to palatable stimulation, or attenuated survival mechanisms after prolonged inbreeding in captivity. However, by revealing the effectiveness of unrestricted drinking of drug-laced sucrose solution on behavior and immunity, the current study supports broader use of such an administration route in behavioural studies sensitive to external stressors.
format	article
author	Minesh Kapadia Hui Zhao Donglai Ma Rupal Hatkar Monica Marchese Boris Sakic
author_facet	Minesh Kapadia Hui Zhao Donglai Ma Rupal Hatkar Monica Marchese Boris Sakic
author_sort	Minesh Kapadia
title	Zoopharmacognosy in diseased laboratory mice: conflicting evidence.
title_short	Zoopharmacognosy in diseased laboratory mice: conflicting evidence.
title_full	Zoopharmacognosy in diseased laboratory mice: conflicting evidence.
title_fullStr	Zoopharmacognosy in diseased laboratory mice: conflicting evidence.
title_full_unstemmed	Zoopharmacognosy in diseased laboratory mice: conflicting evidence.
title_sort	zoopharmacognosy in diseased laboratory mice: conflicting evidence.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/05c958b61c764af4b740505bd29600f4
work_keys_str_mv	AT mineshkapadia zoopharmacognosyindiseasedlaboratorymiceconflictingevidence AT huizhao zoopharmacognosyindiseasedlaboratorymiceconflictingevidence AT donglaima zoopharmacognosyindiseasedlaboratorymiceconflictingevidence AT rupalhatkar zoopharmacognosyindiseasedlaboratorymiceconflictingevidence AT monicamarchese zoopharmacognosyindiseasedlaboratorymiceconflictingevidence AT borissakic zoopharmacognosyindiseasedlaboratorymiceconflictingevidence
_version_	1718439280943038464

Zoopharmacognosy in diseased laboratory mice: conflicting evidence.

Ejemplares similares