Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.

Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae. One important factor for plasminogen activation is the str...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andreas Itzek, Christine M Gillen, Marcus Fulde, Claudia Friedrichs, Arne C Rodloff, Gursharan S Chhatwal, Daniel Patric Nitsche-Schmitz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05c98db2bf874370ac34a0e0053130dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:05c98db2bf874370ac34a0e0053130dc
record_format	dspace
spelling	oai:doaj.org-article:05c98db2bf874370ac34a0e0053130dc2021-11-18T07:02:32ZContribution of plasminogen activation towards the pathogenic potential of oral streptococci.1932-620310.1371/journal.pone.0013826https://doaj.org/article/05c98db2bf874370ac34a0e0053130dc2010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21072208/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae. One important factor for plasminogen activation is the streptococcal α-enolase. Here we report that plasminogen activation is also common in oral streptococci species involved in clinical infection and that it depends on the action of human plasminogen activators. The ability to activate plasminogen did not require full conservation of the internal plasminogen binding sequence motif FYDKERKVY of α-enolase that was previously described as crucial for increased plasminogen binding, activation and virulence. Instead, experiments with recombinant α-enolase variants indicate that the naturally occurring variations do not impair plasminogen binding. In spite of these variations in the internal plasminogen binding motif oral streptococci showed similar activation of plasminogen. We conclude that the pathomechanism of plasminogen activation is conserved in oral streptococci that cause infections in human. This may contribute to their opportunistic pathogenic character that is unfurled in certain niches.Andreas ItzekChristine M GillenMarcus FuldeClaudia FriedrichsArne C RodloffGursharan S ChhatwalDaniel Patric Nitsche-SchmitzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e13826 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andreas Itzek Christine M Gillen Marcus Fulde Claudia Friedrichs Arne C Rodloff Gursharan S Chhatwal Daniel Patric Nitsche-Schmitz Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
description	Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae. One important factor for plasminogen activation is the streptococcal α-enolase. Here we report that plasminogen activation is also common in oral streptococci species involved in clinical infection and that it depends on the action of human plasminogen activators. The ability to activate plasminogen did not require full conservation of the internal plasminogen binding sequence motif FYDKERKVY of α-enolase that was previously described as crucial for increased plasminogen binding, activation and virulence. Instead, experiments with recombinant α-enolase variants indicate that the naturally occurring variations do not impair plasminogen binding. In spite of these variations in the internal plasminogen binding motif oral streptococci showed similar activation of plasminogen. We conclude that the pathomechanism of plasminogen activation is conserved in oral streptococci that cause infections in human. This may contribute to their opportunistic pathogenic character that is unfurled in certain niches.
format	article
author	Andreas Itzek Christine M Gillen Marcus Fulde Claudia Friedrichs Arne C Rodloff Gursharan S Chhatwal Daniel Patric Nitsche-Schmitz
author_facet	Andreas Itzek Christine M Gillen Marcus Fulde Claudia Friedrichs Arne C Rodloff Gursharan S Chhatwal Daniel Patric Nitsche-Schmitz
author_sort	Andreas Itzek
title	Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
title_short	Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
title_full	Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
title_fullStr	Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
title_full_unstemmed	Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
title_sort	contribution of plasminogen activation towards the pathogenic potential of oral streptococci.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/05c98db2bf874370ac34a0e0053130dc
work_keys_str_mv	AT andreasitzek contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci AT christinemgillen contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci AT marcusfulde contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci AT claudiafriedrichs contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci AT arnecrodloff contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci AT gursharanschhatwal contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci AT danielpatricnitscheschmitz contributionofplasminogenactivationtowardsthepathogenicpotentialoforalstreptococci
_version_	1718424019656507392

Contribution of plasminogen activation towards the pathogenic potential of oral streptococci.

Ejemplares similares