Association between maternal depression during pregnancy and newborn DNA methylation

Abstract Around 15–65% of women globally experience depression during pregnancy, prevalence being particularly high in low- and middle-income countries. Prenatal depression has been associated with adverse birth and child development outcomes. DNA methylation (DNAm) may aid in understanding this ass...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emily Drzymalla, Nicole Gladish, Nastassja Koen, Michael P. Epstein, Michael S. Kobor, Heather J. Zar, Dan J. Stein, Anke Hüls
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/05d0258854944a77ae96d617c5104b5e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:05d0258854944a77ae96d617c5104b5e
record_format	dspace
spelling	oai:doaj.org-article:05d0258854944a77ae96d617c5104b5e2021-11-14T12:11:27ZAssociation between maternal depression during pregnancy and newborn DNA methylation10.1038/s41398-021-01697-w2158-3188https://doaj.org/article/05d0258854944a77ae96d617c5104b5e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01697-whttps://doaj.org/toc/2158-3188Abstract Around 15–65% of women globally experience depression during pregnancy, prevalence being particularly high in low- and middle-income countries. Prenatal depression has been associated with adverse birth and child development outcomes. DNA methylation (DNAm) may aid in understanding this association. In this project, we analyzed associations between prenatal depression and DNAm from cord blood from participants of the South African Drakenstein Child Health Study. We examined DNAm in an epigenome-wide association study (EWAS) of 248 mother-child pairs. DNAm was measured using the Infinium MethylationEPIC (N = 145) and the Infinium HumanMethylation450 (N = 103) arrays. Prenatal depression scores, obtained with the Edinburgh Postnatal Depression Scale (EPDS) and the Beck Depression Inventory-II (BDI-II), were analyzed as continuous and dichotomized variables. We used linear robust models to estimate associations between depression and newborn DNAm, adjusted for measured (smoking status, household income, sex, preterm birth, cell type proportions, and genetic principal components) and unmeasured confounding using Cate and Bacon algorithms. Bonferroni correction was used to adjust for multiple testing. DMRcate and dmrff were used to test for differentially methylated regions (DMRs). Differential DNAm was significantly associated with BDI-II variables, in cg16473797 (Δ beta = −1.10E-02, p = 6.87E-08), cg23262030 (Δ beta per BDI-II total IQR = 1.47E-03, p = 1.18E-07), and cg04859497 (Δ beta = −6.42E-02, p = 1.06E-09). Five DMRs were associated with at least two depression variables. Further studies are needed to replicate these findings and investigate their biological impact.Emily DrzymallaNicole GladishNastassja KoenMichael P. EpsteinMichael S. KoborHeather J. ZarDan J. SteinAnke HülsNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Emily Drzymalla Nicole Gladish Nastassja Koen Michael P. Epstein Michael S. Kobor Heather J. Zar Dan J. Stein Anke Hüls Association between maternal depression during pregnancy and newborn DNA methylation
description	Abstract Around 15–65% of women globally experience depression during pregnancy, prevalence being particularly high in low- and middle-income countries. Prenatal depression has been associated with adverse birth and child development outcomes. DNA methylation (DNAm) may aid in understanding this association. In this project, we analyzed associations between prenatal depression and DNAm from cord blood from participants of the South African Drakenstein Child Health Study. We examined DNAm in an epigenome-wide association study (EWAS) of 248 mother-child pairs. DNAm was measured using the Infinium MethylationEPIC (N = 145) and the Infinium HumanMethylation450 (N = 103) arrays. Prenatal depression scores, obtained with the Edinburgh Postnatal Depression Scale (EPDS) and the Beck Depression Inventory-II (BDI-II), were analyzed as continuous and dichotomized variables. We used linear robust models to estimate associations between depression and newborn DNAm, adjusted for measured (smoking status, household income, sex, preterm birth, cell type proportions, and genetic principal components) and unmeasured confounding using Cate and Bacon algorithms. Bonferroni correction was used to adjust for multiple testing. DMRcate and dmrff were used to test for differentially methylated regions (DMRs). Differential DNAm was significantly associated with BDI-II variables, in cg16473797 (Δ beta = −1.10E-02, p = 6.87E-08), cg23262030 (Δ beta per BDI-II total IQR = 1.47E-03, p = 1.18E-07), and cg04859497 (Δ beta = −6.42E-02, p = 1.06E-09). Five DMRs were associated with at least two depression variables. Further studies are needed to replicate these findings and investigate their biological impact.
format	article
author	Emily Drzymalla Nicole Gladish Nastassja Koen Michael P. Epstein Michael S. Kobor Heather J. Zar Dan J. Stein Anke Hüls
author_facet	Emily Drzymalla Nicole Gladish Nastassja Koen Michael P. Epstein Michael S. Kobor Heather J. Zar Dan J. Stein Anke Hüls
author_sort	Emily Drzymalla
title	Association between maternal depression during pregnancy and newborn DNA methylation
title_short	Association between maternal depression during pregnancy and newborn DNA methylation
title_full	Association between maternal depression during pregnancy and newborn DNA methylation
title_fullStr	Association between maternal depression during pregnancy and newborn DNA methylation
title_full_unstemmed	Association between maternal depression during pregnancy and newborn DNA methylation
title_sort	association between maternal depression during pregnancy and newborn dna methylation
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/05d0258854944a77ae96d617c5104b5e
work_keys_str_mv	AT emilydrzymalla associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT nicolegladish associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT nastassjakoen associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT michaelpepstein associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT michaelskobor associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT heatherjzar associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT danjstein associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation AT ankehuls associationbetweenmaternaldepressionduringpregnancyandnewborndnamethylation
_version_	1718429387438686208

Association between maternal depression during pregnancy and newborn DNA methylation

Ejemplares similares