The association between omentin and diabetes: a systematic review and meta-analysis of observational studies

Atefeh As´habi,1,2 Malihe Sadeghi,3,4 Arman Arab,5 Hossein Hajianfar1,21Food Safety Research Center (SALT), Semnan University of Medical Sciences, Semnan, Iran; 2Department of Nutrition, School of Nutrition and Food Sciences, Semnan University of Medical Sciences, Semnan, Iran; 3Health Inf...

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Autores principales:	As´habi A, Sadeghi M, Arab A, Hajianfar H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Omentin Diabetes Impaired glucose tolerance Systematic review Meta-analysis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/05d15c68957c4234a3d1eabeb07fe3af
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spelling	oai:doaj.org-article:05d15c68957c4234a3d1eabeb07fe3af2021-12-02T06:43:54ZThe association between omentin and diabetes: a systematic review and meta-analysis of observational studies1178-7007https://doaj.org/article/05d15c68957c4234a3d1eabeb07fe3af2019-07-01T00:00:00Zhttps://www.dovepress.com/the-association-between-omentin-and-diabetes-a-systematic-review-and-m-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Atefeh As´habi,1,2 Malihe Sadeghi,3,4 Arman Arab,5 Hossein Hajianfar1,21Food Safety Research Center (SALT), Semnan University of Medical Sciences, Semnan, Iran; 2Department of Nutrition, School of Nutrition and Food Sciences, Semnan University of Medical Sciences, Semnan, Iran; 3Health Information Technology Department, Faculty of Paramedics, Semnan University of Medical Sciences, Semnan, Iran; 4Health Information Management, Iran University of Medical Sciences, Tehran, Iran; 5Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, IranAims: A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population.Methods: PubMed, Cochrane’s Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle–Ottawa Quality Assessment Scale was used to assess the quality of each study.Results: A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). The result of our sub-group analysis based on participants’ health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls.Conclusion: We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.Keywords: omentin, diabetes, impaired glucose tolerance, systematic review, meta-analysisAs´habi ASadeghi MArab AHajianfar HDove Medical PressarticleOmentinDiabetesImpaired glucose toleranceSystematic reviewMeta-analysisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1277-1286 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Omentin Diabetes Impaired glucose tolerance Systematic review Meta-analysis Specialties of internal medicine RC581-951
spellingShingle	Omentin Diabetes Impaired glucose tolerance Systematic review Meta-analysis Specialties of internal medicine RC581-951 As´habi A Sadeghi M Arab A Hajianfar H The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
description	Atefeh As´habi,1,2 Malihe Sadeghi,3,4 Arman Arab,5 Hossein Hajianfar1,21Food Safety Research Center (SALT), Semnan University of Medical Sciences, Semnan, Iran; 2Department of Nutrition, School of Nutrition and Food Sciences, Semnan University of Medical Sciences, Semnan, Iran; 3Health Information Technology Department, Faculty of Paramedics, Semnan University of Medical Sciences, Semnan, Iran; 4Health Information Management, Iran University of Medical Sciences, Tehran, Iran; 5Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, IranAims: A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population.Methods: PubMed, Cochrane’s Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle–Ottawa Quality Assessment Scale was used to assess the quality of each study.Results: A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). The result of our sub-group analysis based on participants’ health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls.Conclusion: We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.Keywords: omentin, diabetes, impaired glucose tolerance, systematic review, meta-analysis
format	article
author	As´habi A Sadeghi M Arab A Hajianfar H
author_facet	As´habi A Sadeghi M Arab A Hajianfar H
author_sort	As´habi A
title	The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
title_short	The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
title_full	The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
title_fullStr	The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
title_full_unstemmed	The association between omentin and diabetes: a systematic review and meta-analysis of observational studies
title_sort	association between omentin and diabetes: a systematic review and meta-analysis of observational studies
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/05d15c68957c4234a3d1eabeb07fe3af
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The association between omentin and diabetes: a systematic review and meta-analysis of observational studies

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