Hypothalamic leptin action is mediated by histone deacetylase 5

Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating S...

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Autores principales:	Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe2
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spelling	oai:doaj.org-article:05d180e6a43443a4a0aaf1a16b919fe22021-12-02T14:38:55ZHypothalamic leptin action is mediated by histone deacetylase 510.1038/ncomms107822041-1723https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe22016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10782https://doaj.org/toc/2041-1723Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.Dhiraj G. KabraKatrin PfuhlmannCristina García-CáceresSonja C. SchrieverVeronica Casquero GarcíaAdam Fiseha KebedeEsther Fuente-MartinChitrang TrivediKristy HeppnerN. Henriette UhlenhautBeata LegutkoUma D. KabraYuanqing GaoChun-Xia YiCarmelo QuartaChristoffer ClemmensenBrian FinanTimo D. MüllerCarola W. MeyerMarcelo Paez-PeredaKerstin StemmerStephen C. WoodsDiego Perez-TilveRobert SchneiderEric N. OlsonMatthias H. TschöpPaul T. PflugerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dhiraj G. Kabra Katrin Pfuhlmann Cristina García-Cáceres Sonja C. Schriever Veronica Casquero García Adam Fiseha Kebede Esther Fuente-Martin Chitrang Trivedi Kristy Heppner N. Henriette Uhlenhaut Beata Legutko Uma D. Kabra Yuanqing Gao Chun-Xia Yi Carmelo Quarta Christoffer Clemmensen Brian Finan Timo D. Müller Carola W. Meyer Marcelo Paez-Pereda Kerstin Stemmer Stephen C. Woods Diego Perez-Tilve Robert Schneider Eric N. Olson Matthias H. Tschöp Paul T. Pfluger Hypothalamic leptin action is mediated by histone deacetylase 5
description	Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.
format	article
author	Dhiraj G. Kabra Katrin Pfuhlmann Cristina García-Cáceres Sonja C. Schriever Veronica Casquero García Adam Fiseha Kebede Esther Fuente-Martin Chitrang Trivedi Kristy Heppner N. Henriette Uhlenhaut Beata Legutko Uma D. Kabra Yuanqing Gao Chun-Xia Yi Carmelo Quarta Christoffer Clemmensen Brian Finan Timo D. Müller Carola W. Meyer Marcelo Paez-Pereda Kerstin Stemmer Stephen C. Woods Diego Perez-Tilve Robert Schneider Eric N. Olson Matthias H. Tschöp Paul T. Pfluger
author_facet	Dhiraj G. Kabra Katrin Pfuhlmann Cristina García-Cáceres Sonja C. Schriever Veronica Casquero García Adam Fiseha Kebede Esther Fuente-Martin Chitrang Trivedi Kristy Heppner N. Henriette Uhlenhaut Beata Legutko Uma D. Kabra Yuanqing Gao Chun-Xia Yi Carmelo Quarta Christoffer Clemmensen Brian Finan Timo D. Müller Carola W. Meyer Marcelo Paez-Pereda Kerstin Stemmer Stephen C. Woods Diego Perez-Tilve Robert Schneider Eric N. Olson Matthias H. Tschöp Paul T. Pfluger
author_sort	Dhiraj G. Kabra
title	Hypothalamic leptin action is mediated by histone deacetylase 5
title_short	Hypothalamic leptin action is mediated by histone deacetylase 5
title_full	Hypothalamic leptin action is mediated by histone deacetylase 5
title_fullStr	Hypothalamic leptin action is mediated by histone deacetylase 5
title_full_unstemmed	Hypothalamic leptin action is mediated by histone deacetylase 5
title_sort	hypothalamic leptin action is mediated by histone deacetylase 5
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe2
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Hypothalamic leptin action is mediated by histone deacetylase 5

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