Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos–Ni(I) species

Nitriles are key intermediates in production of pharmaceuticals, agrochemicals and organic materials. Here, the authors report a nickel-catalyzed reductive cyanation of organic chlorides with CO2/NH3 and urea as cyanation reagents to afford a broad range of organic nitriles.

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Detalles Bibliográficos
Autores principales: Yanan Dong, Peiju Yang, Shizhen Zhao, Yuehui Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/05d18c221ec64e6f9d77dfcb44eda4b1
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Sumario:Nitriles are key intermediates in production of pharmaceuticals, agrochemicals and organic materials. Here, the authors report a nickel-catalyzed reductive cyanation of organic chlorides with CO2/NH3 and urea as cyanation reagents to afford a broad range of organic nitriles.