PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.

Pax transactivation domain interacting protein (PTIP) associated protein 1, PA1, was a newly found protein participating in the modulation of transactivity of nuclear receptor super family members such as estrogen receptor (ER), androgen receptor (AR) and glucocorticoid receptor (GR). Breast cancer...

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Autores principales:	Takashi Takeshita, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Yoko Omoto, Yumi Honda, Ken-ichi Iyama, Zhenhuan Zhang, Hirotaka Iwase
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05d19c7c82904aae9b1437d797aa7a45
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spelling	oai:doaj.org-article:05d19c7c82904aae9b1437d797aa7a452021-11-18T08:46:02ZPTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.1932-620310.1371/journal.pone.0080552https://doaj.org/article/05d19c7c82904aae9b1437d797aa7a452013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260416/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Pax transactivation domain interacting protein (PTIP) associated protein 1, PA1, was a newly found protein participating in the modulation of transactivity of nuclear receptor super family members such as estrogen receptor (ER), androgen receptor (AR) and glucocorticoid receptor (GR). Breast cancer is one of the most life threatening diseases for women and has tight association with estrogen and ER. This study was performed to understand the function of PA1 in breast cancer. The expression of PA1 had been evaluated in a total of 344 primary invasive breast cancer samples and examined the relationship with clinical output, relapse free survival (RFS), breast cancer-specific survival (BCSS). PA1 expression was observed in both nucleus and cytoplasm, however, appeared mainly in nuclear. PA1 nuclear expression was correlated with postmenopausal (P = 0.0097), smaller tumor size (P = 0.0025), negative Ki67 (P = 0.02), positive AR (P = 0.049) and positive ERβ (P = 0.0020). Kaplan-Meier analysis demonstrated PA1 nuclear positive cases seemed to have a longer survival than negative ones for RFS (P = 0.023) but not for BCSS (P = 0.23). In the Cox hazards model, PA1 nuclear protein expression proved to be a significant prognostic univariate parameter for RFS (P = 0.03), but not for BCSS (P = 0.20). In addition, for those patients without lymphnode metastasis PA1 was found to be an independent prognostic factor for RFS (P = 0.025), which was verified by univariate and multivariate analyses. These investigations suggested PA1 expression could be a potential prognostic indicator for RFS in breast cancer.Takashi TakeshitaMutsuko Yamamoto-IbusukiYutaka YamamotoYoko OmotoYumi HondaKen-ichi IyamaZhenhuan ZhangHirotaka IwasePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80552 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Takeshita Mutsuko Yamamoto-Ibusuki Yutaka Yamamoto Yoko Omoto Yumi Honda Ken-ichi Iyama Zhenhuan Zhang Hirotaka Iwase PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
description	Pax transactivation domain interacting protein (PTIP) associated protein 1, PA1, was a newly found protein participating in the modulation of transactivity of nuclear receptor super family members such as estrogen receptor (ER), androgen receptor (AR) and glucocorticoid receptor (GR). Breast cancer is one of the most life threatening diseases for women and has tight association with estrogen and ER. This study was performed to understand the function of PA1 in breast cancer. The expression of PA1 had been evaluated in a total of 344 primary invasive breast cancer samples and examined the relationship with clinical output, relapse free survival (RFS), breast cancer-specific survival (BCSS). PA1 expression was observed in both nucleus and cytoplasm, however, appeared mainly in nuclear. PA1 nuclear expression was correlated with postmenopausal (P = 0.0097), smaller tumor size (P = 0.0025), negative Ki67 (P = 0.02), positive AR (P = 0.049) and positive ERβ (P = 0.0020). Kaplan-Meier analysis demonstrated PA1 nuclear positive cases seemed to have a longer survival than negative ones for RFS (P = 0.023) but not for BCSS (P = 0.23). In the Cox hazards model, PA1 nuclear protein expression proved to be a significant prognostic univariate parameter for RFS (P = 0.03), but not for BCSS (P = 0.20). In addition, for those patients without lymphnode metastasis PA1 was found to be an independent prognostic factor for RFS (P = 0.025), which was verified by univariate and multivariate analyses. These investigations suggested PA1 expression could be a potential prognostic indicator for RFS in breast cancer.
format	article
author	Takashi Takeshita Mutsuko Yamamoto-Ibusuki Yutaka Yamamoto Yoko Omoto Yumi Honda Ken-ichi Iyama Zhenhuan Zhang Hirotaka Iwase
author_facet	Takashi Takeshita Mutsuko Yamamoto-Ibusuki Yutaka Yamamoto Yoko Omoto Yumi Honda Ken-ichi Iyama Zhenhuan Zhang Hirotaka Iwase
author_sort	Takashi Takeshita
title	PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
title_short	PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
title_full	PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
title_fullStr	PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
title_full_unstemmed	PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
title_sort	ptip associated protein 1, pa1, is an independent prognostic factor for lymphnode negative breast cancer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/05d19c7c82904aae9b1437d797aa7a45
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_version_	1718421304347983872

PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.

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