<italic toggle="yes">In Vivo</italic> Targeting of <named-content content-type="genus-species">Clostridioides difficile</named-content> Using Phage-Delivered CRISPR-Cas3 Antimicrobials

<italic toggle="yes">In Vivo</italic> Targeting of <named-content content-type="genus-species">Clostridioides difficile</named-content> Using Phage-Delivered CRISPR-Cas3 Antimicrobials

ABSTRACT Clostridioides difficile is an important nosocomial pathogen that causes approximately 500,000 cases of C. difficile infection (CDI) and 29,000 deaths annually in the United States. Antibiotic use is a major risk factor for CDI because broad-spectrum antimicrobials disrupt the indigenous gu...

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Autores principales: Kurt Selle, Joshua R. Fletcher, Hannah Tuson, Daniel S. Schmitt, Lana McMillan, Gowrinarayani S. Vridhambal, Alissa J. Rivera, Stephanie A. Montgomery, Louis-Charles Fortier, Rodolphe Barrangou, Casey M. Theriot, David G. Ousterout
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Clostridioides difficile
CRISPR-Cas
Cas3
phage
lysogeny
CRISPR
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/05d3dd5ddad5489e8af88e62d8ba3612
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