Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.

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Autores principales:	Justin I. Yoo, Patrick S. Daugherty, Michelle A. O’Malley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05d4a1f9278e456eb4e1635dc620ccf7
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spelling	oai:doaj.org-article:05d4a1f9278e456eb4e1635dc620ccf72021-12-02T17:32:11ZBridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR10.1038/s41467-020-14495-72041-1723https://doaj.org/article/05d4a1f9278e456eb4e1635dc620ccf72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14495-7https://doaj.org/toc/2041-1723Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.Justin I. YooPatrick S. DaughertyMichelle A. O’MalleyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Justin I. Yoo Patrick S. Daugherty Michelle A. O’Malley Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
description	Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.
format	article
author	Justin I. Yoo Patrick S. Daugherty Michelle A. O’Malley
author_facet	Justin I. Yoo Patrick S. Daugherty Michelle A. O’Malley
author_sort	Justin I. Yoo
title	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_short	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_full	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_fullStr	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_full_unstemmed	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_sort	bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a gpcr
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/05d4a1f9278e456eb4e1635dc620ccf7
work_keys_str_mv	AT justiniyoo bridgingnonoverlappingreadsilluminateshighorderepistasisbetweendistalproteinsitesinagpcr AT patricksdaugherty bridgingnonoverlappingreadsilluminateshighorderepistasisbetweendistalproteinsitesinagpcr AT michelleaomalley bridgingnonoverlappingreadsilluminateshighorderepistasisbetweendistalproteinsitesinagpcr
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Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

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