Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Ob...

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Autores principales: Lee JH, Jung WS, Choi WH, Lim HK
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Alzheimer’s disease
sleep
brainstem
MRI
shape analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/05d84df6e1a44d41956a4dc1c16ba796
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spelling oai:doaj.org-article:05d84df6e1a44d41956a4dc1c16ba7962021-12-02T02:49:41ZAberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease1178-2021https://doaj.org/article/05d84df6e1a44d41956a4dc1c16ba7962016-08-01T00:00:00Zhttps://www.dovepress.com/aberrant-brain-stem-morphometry-associated-with-sleep-disturbance-in-d-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD), sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysisLee JHJung WSChoi WHLim HKDove Medical PressarticleAlzheimer’s diseasesleepbrainstemMRIshape analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2089-2093 (2016)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer’s disease
sleep
brainstem
MRI
shape analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Alzheimer’s disease
sleep
brainstem
MRI
shape analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Lee JH
Jung WS
Choi WH
Lim HK
Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
description Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD), sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis
format article
author Lee JH
Jung WS
Choi WH
Lim HK
author_facet Lee JH
Jung WS
Choi WH
Lim HK
author_sort Lee JH
title Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
title_short Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
title_full Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
title_fullStr Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
title_full_unstemmed Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
title_sort aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with alzheimer's disease
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/05d84df6e1a44d41956a4dc1c16ba796
work_keys_str_mv AT leejh aberrantbrainstemmorphometryassociatedwithsleepdisturbanceindrugnaiumlvesubjectswithalzheimer39sdisease
AT jungws aberrantbrainstemmorphometryassociatedwithsleepdisturbanceindrugnaiumlvesubjectswithalzheimer39sdisease
AT choiwh aberrantbrainstemmorphometryassociatedwithsleepdisturbanceindrugnaiumlvesubjectswithalzheimer39sdisease
AT limhk aberrantbrainstemmorphometryassociatedwithsleepdisturbanceindrugnaiumlvesubjectswithalzheimer39sdisease
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