Impact of obesity on outcome of severe bacterial infections.

<h4>Introduction</h4>Obesity is a rapidly growing global health concern with considerable negative impact on life-time expectancy. It has yet not been clarified if and how obesity impacts outcomes of severe bacterial infections. The aim of this study was to determine how body mass index...

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Autores principales:	Åsa Alsiö, Salmir Nasic, Lars Ljungström, Gunnar Jacobsson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05dcab020e0a4c7ead820cb99e3d64e5
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spelling	oai:doaj.org-article:05dcab020e0a4c7ead820cb99e3d64e52021-12-02T20:11:18ZImpact of obesity on outcome of severe bacterial infections.1932-620310.1371/journal.pone.0251887https://doaj.org/article/05dcab020e0a4c7ead820cb99e3d64e52021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251887https://doaj.org/toc/1932-6203<h4>Introduction</h4>Obesity is a rapidly growing global health concern with considerable negative impact on life-time expectancy. It has yet not been clarified if and how obesity impacts outcomes of severe bacterial infections. The aim of this study was to determine how body mass index impacts outcome of severe bacterial infections in a well-defined population-based cohort.<h4>Methods</h4>This study is based on a cohort of 2196 patients included in a Swedish prospective, population-based, consecutive observational study of the incidence of community-onset severe sepsis and septic shock in adults. All patients with weight and height documented in the medical records on admission were included.<h4>Results</h4>The case fatality rate (CFR) was negatively correlating with increasing BMI. Outcomes included 28-day CFR (p-value = 0.002), hospital CFR (p-value = 0.039) and 1-year CFR (p-value<0.001). When BMI was applied as continuous variable in a multiple logistic regression together with other possible covariates, we still could discern that BMI was associated with decreasing 28-day CFR (OR = 0.93, 95% CI 0.88-0.98, p-value = 0.009) and 1-year CFR (OR = 0.94, 95% CI 0.91-0.97, p-value<0.001).<h4>Conclusion</h4>The hypothesis and paradox of obesity being associated with higher survival rates in severe bacterial infections was confirmed in this prospective, population-based observational study.Åsa AlsiöSalmir NasicLars LjungströmGunnar JacobssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251887 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Åsa Alsiö Salmir Nasic Lars Ljungström Gunnar Jacobsson Impact of obesity on outcome of severe bacterial infections.
description	<h4>Introduction</h4>Obesity is a rapidly growing global health concern with considerable negative impact on life-time expectancy. It has yet not been clarified if and how obesity impacts outcomes of severe bacterial infections. The aim of this study was to determine how body mass index impacts outcome of severe bacterial infections in a well-defined population-based cohort.<h4>Methods</h4>This study is based on a cohort of 2196 patients included in a Swedish prospective, population-based, consecutive observational study of the incidence of community-onset severe sepsis and septic shock in adults. All patients with weight and height documented in the medical records on admission were included.<h4>Results</h4>The case fatality rate (CFR) was negatively correlating with increasing BMI. Outcomes included 28-day CFR (p-value = 0.002), hospital CFR (p-value = 0.039) and 1-year CFR (p-value<0.001). When BMI was applied as continuous variable in a multiple logistic regression together with other possible covariates, we still could discern that BMI was associated with decreasing 28-day CFR (OR = 0.93, 95% CI 0.88-0.98, p-value = 0.009) and 1-year CFR (OR = 0.94, 95% CI 0.91-0.97, p-value<0.001).<h4>Conclusion</h4>The hypothesis and paradox of obesity being associated with higher survival rates in severe bacterial infections was confirmed in this prospective, population-based observational study.
format	article
author	Åsa Alsiö Salmir Nasic Lars Ljungström Gunnar Jacobsson
author_facet	Åsa Alsiö Salmir Nasic Lars Ljungström Gunnar Jacobsson
author_sort	Åsa Alsiö
title	Impact of obesity on outcome of severe bacterial infections.
title_short	Impact of obesity on outcome of severe bacterial infections.
title_full	Impact of obesity on outcome of severe bacterial infections.
title_fullStr	Impact of obesity on outcome of severe bacterial infections.
title_full_unstemmed	Impact of obesity on outcome of severe bacterial infections.
title_sort	impact of obesity on outcome of severe bacterial infections.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/05dcab020e0a4c7ead820cb99e3d64e5
work_keys_str_mv	AT asaalsio impactofobesityonoutcomeofseverebacterialinfections AT salmirnasic impactofobesityonoutcomeofseverebacterialinfections AT larsljungstrom impactofobesityonoutcomeofseverebacterialinfections AT gunnarjacobsson impactofobesityonoutcomeofseverebacterialinfections
_version_	1718374864707911680

Impact of obesity on outcome of severe bacterial infections.

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