Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses

In this study, we compared the cytological, histopathological, and immunohistochemical diagnoses of 71 canine cutaneous and subcutaneous masses. Cytological diagnoses included 56 tumors (21 mesenchymal, 15 epithelial, 16 round cell, four melanocytic), 13 inflammatory reactions, and two cysts. Of the...

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Autores principales:	Ipek Volkan, Cangul I. Taci, Akkoc Ahmet
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	dog cytology histopathology immunohistochemistry skin tumor Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/05dd0dc767834538ac01a275efdf406e
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spelling	oai:doaj.org-article:05dd0dc767834538ac01a275efdf406e2021-11-17T21:27:54ZComparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses1820-744810.2478/acve-2021-0005https://doaj.org/article/05dd0dc767834538ac01a275efdf406e2021-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2021-0005https://doaj.org/toc/1820-7448In this study, we compared the cytological, histopathological, and immunohistochemical diagnoses of 71 canine cutaneous and subcutaneous masses. Cytological diagnoses included 56 tumors (21 mesenchymal, 15 epithelial, 16 round cell, four melanocytic), 13 inflammatory reactions, and two cysts. Of the 21 cytologically diagnosed mesenchymal tumors, three were later confirmed non-tumoral (hematoma, granulation tissue, fibroepithelial polyp). Thirteen out of 15 epithelial tumors were correctly diagnosed cytologically, whereas two cases were confirmed to be non-tumoral (fibroepithelial polyp, granulation tissue) after histopathological examination. One mast cell tumor was later confirmed as fibrous hyperplasia; diagnoses were correct in other round cell tumors. Cytological diagnoses were correct for all melanocytic tumors and cystic lesions. Five cases which had been cytologically diagnosed as inflammatory reactions were diagnosed as tumors (lymphoma, papilloma, sebaceous adenoma, and squamous cell carcinoma) after histopathological examination. Immunohistochemistry confirmed the histopathological diagnoses of all epithelial and round cell tumors, while the diagnoses of six mesenchymal tumors were changed after the immunohistochemical examination. The total accuracy of cytology in the diagnosis of tumoral/non-tumoral masses was 84.5%, and the accuracy in the determination of benign/malignant behavior was 83%. Diagnostic accordance between histopathology and immunohistochemistry was 86.6%. High success rates obtained with cytological diagnoses prove that cytology is a reliable diagnostic tool. The main diagnostic challenge remains with mesenchymal tumors and tumors accompanied by inflammatory reactions. The results suggest that immunohistochemistry is fundamental for diagnoses of most mesenchymal tumors.Ipek VolkanCangul I. TaciAkkoc AhmetSciendoarticledogcytologyhistopathologyimmunohistochemistryskintumorVeterinary medicineSF600-1100ENActa Veterinaria, Vol 71, Iss 1, Pp 61-84 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dog cytology histopathology immunohistochemistry skin tumor Veterinary medicine SF600-1100
spellingShingle	dog cytology histopathology immunohistochemistry skin tumor Veterinary medicine SF600-1100 Ipek Volkan Cangul I. Taci Akkoc Ahmet Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses
description	In this study, we compared the cytological, histopathological, and immunohistochemical diagnoses of 71 canine cutaneous and subcutaneous masses. Cytological diagnoses included 56 tumors (21 mesenchymal, 15 epithelial, 16 round cell, four melanocytic), 13 inflammatory reactions, and two cysts. Of the 21 cytologically diagnosed mesenchymal tumors, three were later confirmed non-tumoral (hematoma, granulation tissue, fibroepithelial polyp). Thirteen out of 15 epithelial tumors were correctly diagnosed cytologically, whereas two cases were confirmed to be non-tumoral (fibroepithelial polyp, granulation tissue) after histopathological examination. One mast cell tumor was later confirmed as fibrous hyperplasia; diagnoses were correct in other round cell tumors. Cytological diagnoses were correct for all melanocytic tumors and cystic lesions. Five cases which had been cytologically diagnosed as inflammatory reactions were diagnosed as tumors (lymphoma, papilloma, sebaceous adenoma, and squamous cell carcinoma) after histopathological examination. Immunohistochemistry confirmed the histopathological diagnoses of all epithelial and round cell tumors, while the diagnoses of six mesenchymal tumors were changed after the immunohistochemical examination. The total accuracy of cytology in the diagnosis of tumoral/non-tumoral masses was 84.5%, and the accuracy in the determination of benign/malignant behavior was 83%. Diagnostic accordance between histopathology and immunohistochemistry was 86.6%. High success rates obtained with cytological diagnoses prove that cytology is a reliable diagnostic tool. The main diagnostic challenge remains with mesenchymal tumors and tumors accompanied by inflammatory reactions. The results suggest that immunohistochemistry is fundamental for diagnoses of most mesenchymal tumors.
format	article
author	Ipek Volkan Cangul I. Taci Akkoc Ahmet
author_facet	Ipek Volkan Cangul I. Taci Akkoc Ahmet
author_sort	Ipek Volkan
title	Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses
title_short	Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses
title_full	Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses
title_fullStr	Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses
title_full_unstemmed	Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses
title_sort	comparative evaluation of the cytological, histopathological and immunohistochemical findings of canine cutaneous and subcutaneous masses
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/05dd0dc767834538ac01a275efdf406e
work_keys_str_mv	AT ipekvolkan comparativeevaluationofthecytologicalhistopathologicalandimmunohistochemicalfindingsofcaninecutaneousandsubcutaneousmasses AT cangulitaci comparativeevaluationofthecytologicalhistopathologicalandimmunohistochemicalfindingsofcaninecutaneousandsubcutaneousmasses AT akkocahmet comparativeevaluationofthecytologicalhistopathologicalandimmunohistochemicalfindingsofcaninecutaneousandsubcutaneousmasses
_version_	1718425266580094976

Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses

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