SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS

Objective: To identify the spectrum of organisms in intensive care unit (ICU) in patients who were receiving proton pump inhibitors for stress ulcer prophylaxis and diagnosed as having hospital-acquired pneumonia (HAP). Study Design: Cross sectional study. Place and Duration of Study: Shifa Inte...

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Autores principales:	Aaqib Jahangir Khan, Aftab Akhtar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	hospital acquired pneumonia proton pump inhibitors stress ulcer prophylaxis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/05e7ed7936594ef293c8481ef1d956d4
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spelling	oai:doaj.org-article:05e7ed7936594ef293c8481ef1d956d42021-12-02T07:04:39ZSPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS0030-96482411-8842https://doaj.org/article/05e7ed7936594ef293c8481ef1d956d42018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2315/2009https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To identify the spectrum of organisms in intensive care unit (ICU) in patients who were receiving proton pump inhibitors for stress ulcer prophylaxis and diagnosed as having hospital-acquired pneumonia (HAP). Study Design: Cross sectional study. Place and Duration of Study: Shifa International Hospital Islamabad, from Apr 2016 to Aug 2016. Material and Methods: One hundred and forty eight patients (134 receiving PPI’s and 14 not receiving) in MICU of Shifa International Hospital were included in this study. Hospital acquired pneumonia was defined as New chest infiltrates developing within 48 hours of admission, Fever of greater than 38 degrees Celsius and total leucocyte count of more than 11000 or less than 3500. In all patients tracheal cultures were followed at 24 and 48 hours and microbiologic spectrum was defined. Results: Out of 148 patients admitted to ICU during the study period, 45 patients (33.6 percent) developed HAP in PPI group compared to 1 in non PPI group. The initial tracheal cultures at admission were negative. Out of the 45 patients who fulfilled criteria for HAP 40 patients (89%) had positive tracheal cultures for gram negative bacteria which included Acinetobacter, Klebsiella and Escheria species. The cultures remained negative for 5 patients (11%) with HAP. The 89 patients who didn’t fulfill the criteria for HAP, 25 patients still had positive tracheal cultures but more than fifty percent of the cultures yielded Candida Albicans. In the non PPI group only 1 patient developed HAP. HAP incidence was PPI group (p 0.042). Conclusion: Gram negative bacteria was prevailed as the causative organism in patients who developed hospital acquired pneumonia (89 percent) and receiving proton pump inhibitors in medical intensive care unit with greater number incidence of HAP in PPI group.Aaqib Jahangir KhanAftab AkhtarArmy Medical College Rawalpindiarticlehospital acquired pneumoniaproton pump inhibitorsstress ulcer prophylaxisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1318-1322 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	hospital acquired pneumonia proton pump inhibitors stress ulcer prophylaxis Medicine R Medicine (General) R5-920
spellingShingle	hospital acquired pneumonia proton pump inhibitors stress ulcer prophylaxis Medicine R Medicine (General) R5-920 Aaqib Jahangir Khan Aftab Akhtar SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS
description	Objective: To identify the spectrum of organisms in intensive care unit (ICU) in patients who were receiving proton pump inhibitors for stress ulcer prophylaxis and diagnosed as having hospital-acquired pneumonia (HAP). Study Design: Cross sectional study. Place and Duration of Study: Shifa International Hospital Islamabad, from Apr 2016 to Aug 2016. Material and Methods: One hundred and forty eight patients (134 receiving PPI’s and 14 not receiving) in MICU of Shifa International Hospital were included in this study. Hospital acquired pneumonia was defined as New chest infiltrates developing within 48 hours of admission, Fever of greater than 38 degrees Celsius and total leucocyte count of more than 11000 or less than 3500. In all patients tracheal cultures were followed at 24 and 48 hours and microbiologic spectrum was defined. Results: Out of 148 patients admitted to ICU during the study period, 45 patients (33.6 percent) developed HAP in PPI group compared to 1 in non PPI group. The initial tracheal cultures at admission were negative. Out of the 45 patients who fulfilled criteria for HAP 40 patients (89%) had positive tracheal cultures for gram negative bacteria which included Acinetobacter, Klebsiella and Escheria species. The cultures remained negative for 5 patients (11%) with HAP. The 89 patients who didn’t fulfill the criteria for HAP, 25 patients still had positive tracheal cultures but more than fifty percent of the cultures yielded Candida Albicans. In the non PPI group only 1 patient developed HAP. HAP incidence was PPI group (p 0.042). Conclusion: Gram negative bacteria was prevailed as the causative organism in patients who developed hospital acquired pneumonia (89 percent) and receiving proton pump inhibitors in medical intensive care unit with greater number incidence of HAP in PPI group.
format	article
author	Aaqib Jahangir Khan Aftab Akhtar
author_facet	Aaqib Jahangir Khan Aftab Akhtar
author_sort	Aaqib Jahangir Khan
title	SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS
title_short	SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS
title_full	SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS
title_fullStr	SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS
title_full_unstemmed	SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS
title_sort	spectrum of culture positive hospital acquired pneumonia in patients receiving proton pump inhibitors
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/05e7ed7936594ef293c8481ef1d956d4
work_keys_str_mv	AT aaqibjahangirkhan spectrumofculturepositivehospitalacquiredpneumoniainpatientsreceivingprotonpumpinhibitors AT aftabakhtar spectrumofculturepositivehospitalacquiredpneumoniainpatientsreceivingprotonpumpinhibitors
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SPECTRUM OF CULTURE POSITIVE HOSPITAL ACQUIRED PNEUMONIA IN PATIENTS RECEIVING PROTON PUMP INHIBITORS

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