Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma

Jinying Liang,1–3 Xinxin Zhang,2 Yunqiu Miao,2 Juan Li,1 Yong Gan2 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of Chi...

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Autores principales:	Liang J, Zhang X, Miao Y, Li J, Gan Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Dual-imaging magnetic resonance imaging (MRI) hepatocellular carcinoma tumor-targeting Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/05e94422433c4ee497e47f98581cacb6
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spelling	oai:doaj.org-article:05e94422433c4ee497e47f98581cacb62021-12-02T03:05:08ZLipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma1178-2013https://doaj.org/article/05e94422433c4ee497e47f98581cacb62017-03-01T00:00:00Zhttps://www.dovepress.com/lipid-coated-iron-oxide-nanoparticles-for-dual-modal-imaging-of-hepato-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jinying Liang,1–3 Xinxin Zhang,2 Yunqiu Miao,2 Juan Li,1 Yong Gan2 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China; 3School of Pharmacy, Xinxiang Medical University, Xinxiang, People’s Republic of China Abstract: The development of noninvasive imaging techniques for the accurate diagnosis of progressive hepatocellular carcinoma (HCC) is of great clinical significance and has always been desired. Herein, a hepatocellular carcinoma cell-targeting fluorescent magnetic nanoparticle (NP) was obtained by conjugating near-infrared fluorescence to the surface of Fe3O4 (NIRF-Fe3O4) NPs, followed by coating the lipids consisting of tumoral hepatocytes-targeting polymer (Gal-P123). This magnetic NP (GPC@NIRF-Fe3O4) with superparamagnetic behavior showed high stability and safety in physiological conditions. In addition, GPC@NIRF-Fe3O4 achieved more specific uptake of human liver cancer cells than free Fe3O4 NPs. Importantly, with superparamagnetic iron oxide and strong NIR absorbance, GPC@NIRF-Fe3O4 NPs demonstrate prominent tumor-contrasted imaging performance both on fluorescent and T2-weighted magnetic resonance (MR) imaging modalities in a living body. The relative MR signal enhancement of GPC@NIRF-Fe3O4 NPs achieved 5.4-fold improvement compared with NIR-Fe3O4 NPs. Therefore, GPC@NIRF-Fe3O4 NPs may be potentially used as a candidate for dual-modal imaging of tumors with information covalidated and directly compared by combining fluorescence and MR imaging. Keywords: dual-imaging, magnetic resonance imaging, hepatocellular carcinoma, tumor-targetingLiang JZhang XMiao YLi JGan YDove Medical PressarticleDual-imagingmagnetic resonance imaging (MRI)hepatocellular carcinomatumor-targetingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2033-2044 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dual-imaging magnetic resonance imaging (MRI) hepatocellular carcinoma tumor-targeting Medicine (General) R5-920
spellingShingle	Dual-imaging magnetic resonance imaging (MRI) hepatocellular carcinoma tumor-targeting Medicine (General) R5-920 Liang J Zhang X Miao Y Li J Gan Y Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
description	Jinying Liang,1–3 Xinxin Zhang,2 Yunqiu Miao,2 Juan Li,1 Yong Gan2 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People’s Republic of China; 3School of Pharmacy, Xinxiang Medical University, Xinxiang, People’s Republic of China Abstract: The development of noninvasive imaging techniques for the accurate diagnosis of progressive hepatocellular carcinoma (HCC) is of great clinical significance and has always been desired. Herein, a hepatocellular carcinoma cell-targeting fluorescent magnetic nanoparticle (NP) was obtained by conjugating near-infrared fluorescence to the surface of Fe3O4 (NIRF-Fe3O4) NPs, followed by coating the lipids consisting of tumoral hepatocytes-targeting polymer (Gal-P123). This magnetic NP (GPC@NIRF-Fe3O4) with superparamagnetic behavior showed high stability and safety in physiological conditions. In addition, GPC@NIRF-Fe3O4 achieved more specific uptake of human liver cancer cells than free Fe3O4 NPs. Importantly, with superparamagnetic iron oxide and strong NIR absorbance, GPC@NIRF-Fe3O4 NPs demonstrate prominent tumor-contrasted imaging performance both on fluorescent and T2-weighted magnetic resonance (MR) imaging modalities in a living body. The relative MR signal enhancement of GPC@NIRF-Fe3O4 NPs achieved 5.4-fold improvement compared with NIR-Fe3O4 NPs. Therefore, GPC@NIRF-Fe3O4 NPs may be potentially used as a candidate for dual-modal imaging of tumors with information covalidated and directly compared by combining fluorescence and MR imaging. Keywords: dual-imaging, magnetic resonance imaging, hepatocellular carcinoma, tumor-targeting
format	article
author	Liang J Zhang X Miao Y Li J Gan Y
author_facet	Liang J Zhang X Miao Y Li J Gan Y
author_sort	Liang J
title	Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
title_short	Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
title_full	Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
title_fullStr	Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
title_full_unstemmed	Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
title_sort	lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/05e94422433c4ee497e47f98581cacb6
work_keys_str_mv	AT liangj lipidcoatedironoxidenanoparticlesfordualmodalimagingofhepatocellularcarcinoma AT zhangx lipidcoatedironoxidenanoparticlesfordualmodalimagingofhepatocellularcarcinoma AT miaoy lipidcoatedironoxidenanoparticlesfordualmodalimagingofhepatocellularcarcinoma AT lij lipidcoatedironoxidenanoparticlesfordualmodalimagingofhepatocellularcarcinoma AT gany lipidcoatedironoxidenanoparticlesfordualmodalimagingofhepatocellularcarcinoma
_version_	1718401960194867200

Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma

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