Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics

Applying neutralizing antibodies against SARS-CoV-2 to infected patients is a promising anti-viral treatment strategy. Here, Zhao et al. derive RBD-targeting monoclonal antibodies from a naïve human phage-displayed Fab library and show their prophylactic and therapeutic potential in hACE2-transgeni...

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Auteurs principaux:	Shaojuan Zhao, Huajun Zhang, Xinglou Yang, Haiwei Zhang, Ying Chen, Yancheng Zhan, Xiaoqing Zhang, Rendi Jiang, Meiqin Liu, Lan Liu, Li Chen, Wei Tang, Cheng Peng, Xiaoxiao Gao, Zhe Zhang, Zhengli Shi, Rui Gong
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/05eb0eaef7d04ecebe14fe081a7343ed
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spelling	oai:doaj.org-article:05eb0eaef7d04ecebe14fe081a7343ed2021-12-02T16:28:52ZIdentification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics10.1038/s41467-021-25153-x2041-1723https://doaj.org/article/05eb0eaef7d04ecebe14fe081a7343ed2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25153-xhttps://doaj.org/toc/2041-1723Applying neutralizing antibodies against SARS-CoV-2 to infected patients is a promising anti-viral treatment strategy. Here, Zhao et al. derive RBD-targeting monoclonal antibodies from a naïve human phage-displayed Fab library and show their prophylactic and therapeutic potential in hACE2-transgenic mice.Shaojuan ZhaoHuajun ZhangXinglou YangHaiwei ZhangYing ChenYancheng ZhanXiaoqing ZhangRendi JiangMeiqin LiuLan LiuLi ChenWei TangCheng PengXiaoxiao GaoZhe ZhangZhengli ShiRui GongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaojuan Zhao Huajun Zhang Xinglou Yang Haiwei Zhang Ying Chen Yancheng Zhan Xiaoqing Zhang Rendi Jiang Meiqin Liu Lan Liu Li Chen Wei Tang Cheng Peng Xiaoxiao Gao Zhe Zhang Zhengli Shi Rui Gong Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics
description	Applying neutralizing antibodies against SARS-CoV-2 to infected patients is a promising anti-viral treatment strategy. Here, Zhao et al. derive RBD-targeting monoclonal antibodies from a naïve human phage-displayed Fab library and show their prophylactic and therapeutic potential in hACE2-transgenic mice.
format	article
author	Shaojuan Zhao Huajun Zhang Xinglou Yang Haiwei Zhang Ying Chen Yancheng Zhan Xiaoqing Zhang Rendi Jiang Meiqin Liu Lan Liu Li Chen Wei Tang Cheng Peng Xiaoxiao Gao Zhe Zhang Zhengli Shi Rui Gong
author_facet	Shaojuan Zhao Huajun Zhang Xinglou Yang Haiwei Zhang Ying Chen Yancheng Zhan Xiaoqing Zhang Rendi Jiang Meiqin Liu Lan Liu Li Chen Wei Tang Cheng Peng Xiaoxiao Gao Zhe Zhang Zhengli Shi Rui Gong
author_sort	Shaojuan Zhao
title	Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics
title_short	Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics
title_full	Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics
title_fullStr	Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics
title_full_unstemmed	Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics
title_sort	identification of potent human neutralizing antibodies against sars-cov-2 implications for development of therapeutics and prophylactics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05eb0eaef7d04ecebe14fe081a7343ed
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Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics

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