Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis

Background: Leptomeningeal metastasis (LM) creates symptoms related to both the disease within the nervous system and treatment toxicities. Biologic processes, such as inflammation and behavioral processes, such as the meaning ascribed to illness (Meaning of Illness: MoI), can impact physical and ps...

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Autores principales:	Julie G. Walker, Terri S. Armstrong, Barbara J. O'Brien, Mark R. Gilbert, Rebecca L. Casarez, Christopher Fagundes, Cobi J. Heijnen, Clark R. Andersen, Ying Yuan, Jimin Wu, Geri LoBiondo-Wood
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Leptomeningeal metastasis Meaning of illness Quality of life Depression Symptoms Cytokine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990
Acceso en línea:	https://doaj.org/article/05f08b960ffd481185a8febca67c387b
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spelling	oai:doaj.org-article:05f08b960ffd481185a8febca67c387b2021-12-04T04:36:04ZAssociations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis2666-497610.1016/j.cpnec.2021.100099https://doaj.org/article/05f08b960ffd481185a8febca67c387b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666497621000734https://doaj.org/toc/2666-4976Background: Leptomeningeal metastasis (LM) creates symptoms related to both the disease within the nervous system and treatment toxicities. Biologic processes, such as inflammation and behavioral processes, such as the meaning ascribed to illness (Meaning of Illness: MoI), can impact physical and psychosocial symptoms. The aim of this study was to understand the relationships among MoI, physical and psychosocial symptoms, and inflammation in patients with LM. Methods: Thirty enrolled participants completed the MD Anderson Symptom Inventory-Brain Tumor with spine experimental symptoms added. Meaning of illness, quality of life (QoL), and depression were captured by validated instruments. Interleukin (IL)-6 and tumor necrosis factor (TNF)-α in serum and cerebrospinal fluid (CSF) were measured by ELISA. Correlations were performed to assess relationships among the variables. Results: Participants were primarily white (73%), female (63%). Median age was 54 years (34–83). Breast (50%) and lung (20%) were most common diagnosis. Higher MoI scores were associated with better QoL (p < .01) and fewer depressive symptoms (p < .01). All CSF samples contained IL-6 and all but one sample had elevated IL-6. Higher levels of IL-6 in the CSF were associated with greater symptom burden (p < .01) and interference of symptoms in daily life (p = .02) but not MoI. Conclusions: MoI was associated with QoL and depression. High levels of IL-6 in the CSF were associated with more severe symptoms. This study provides the groundwork for future research, including interventional studies to improve QoL in patients with LM.Julie G. WalkerTerri S. ArmstrongBarbara J. O'BrienMark R. GilbertRebecca L. CasarezChristopher FagundesCobi J. HeijnenClark R. AndersenYing YuanJimin WuGeri LoBiondo-WoodElsevierarticleLeptomeningeal metastasisMeaning of illnessQuality of lifeDepressionSymptomsCytokineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571PsychologyBF1-990ENComprehensive Psychoneuroendocrinology, Vol 8, Iss , Pp 100099- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Leptomeningeal metastasis Meaning of illness Quality of life Depression Symptoms Cytokine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990
spellingShingle	Leptomeningeal metastasis Meaning of illness Quality of life Depression Symptoms Cytokine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990 Julie G. Walker Terri S. Armstrong Barbara J. O'Brien Mark R. Gilbert Rebecca L. Casarez Christopher Fagundes Cobi J. Heijnen Clark R. Andersen Ying Yuan Jimin Wu Geri LoBiondo-Wood Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis
description	Background: Leptomeningeal metastasis (LM) creates symptoms related to both the disease within the nervous system and treatment toxicities. Biologic processes, such as inflammation and behavioral processes, such as the meaning ascribed to illness (Meaning of Illness: MoI), can impact physical and psychosocial symptoms. The aim of this study was to understand the relationships among MoI, physical and psychosocial symptoms, and inflammation in patients with LM. Methods: Thirty enrolled participants completed the MD Anderson Symptom Inventory-Brain Tumor with spine experimental symptoms added. Meaning of illness, quality of life (QoL), and depression were captured by validated instruments. Interleukin (IL)-6 and tumor necrosis factor (TNF)-α in serum and cerebrospinal fluid (CSF) were measured by ELISA. Correlations were performed to assess relationships among the variables. Results: Participants were primarily white (73%), female (63%). Median age was 54 years (34–83). Breast (50%) and lung (20%) were most common diagnosis. Higher MoI scores were associated with better QoL (p < .01) and fewer depressive symptoms (p < .01). All CSF samples contained IL-6 and all but one sample had elevated IL-6. Higher levels of IL-6 in the CSF were associated with greater symptom burden (p < .01) and interference of symptoms in daily life (p = .02) but not MoI. Conclusions: MoI was associated with QoL and depression. High levels of IL-6 in the CSF were associated with more severe symptoms. This study provides the groundwork for future research, including interventional studies to improve QoL in patients with LM.
format	article
author	Julie G. Walker Terri S. Armstrong Barbara J. O'Brien Mark R. Gilbert Rebecca L. Casarez Christopher Fagundes Cobi J. Heijnen Clark R. Andersen Ying Yuan Jimin Wu Geri LoBiondo-Wood
author_facet	Julie G. Walker Terri S. Armstrong Barbara J. O'Brien Mark R. Gilbert Rebecca L. Casarez Christopher Fagundes Cobi J. Heijnen Clark R. Andersen Ying Yuan Jimin Wu Geri LoBiondo-Wood
author_sort	Julie G. Walker
title	Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis
title_short	Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis
title_full	Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis
title_fullStr	Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis
title_full_unstemmed	Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis
title_sort	associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with leptomeningeal metastasis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/05f08b960ffd481185a8febca67c387b
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Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis

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