Novel characterization of lymphatic valve formation during corneal inflammation.

Lymphatic research has progressed rapidly in recent years. Though lymphatic dysfunction has been found in a wide array of disorders from transplant rejection to cancer metastasis, to date, there is still little effective treatment for lymphatic diseases. The cornea offers an optimal site for lymphat...

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Autores principales:	Tan Truong, Eda Altiok, Don Yuen, Tatiana Ecoiffier, Lu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05f11e30d74745028902cbad714c2875
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spelling	oai:doaj.org-article:05f11e30d74745028902cbad714c28752021-11-18T06:50:37ZNovel characterization of lymphatic valve formation during corneal inflammation.1932-620310.1371/journal.pone.0021918https://doaj.org/article/05f11e30d74745028902cbad714c28752011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21760922/?tool=EBIhttps://doaj.org/toc/1932-6203Lymphatic research has progressed rapidly in recent years. Though lymphatic dysfunction has been found in a wide array of disorders from transplant rejection to cancer metastasis, to date, there is still little effective treatment for lymphatic diseases. The cornea offers an optimal site for lymphatic research due to its accessible location, transparent nature, and lymphatic-free but inducible features. However, it still remains unknown whether lymphatic valves exist in newly formed lymphatic vessels in the cornea, and how this relates to an inflammatory response. In this study, we provide the first evidence showing that lymphatic valves were formed in mouse cornea during suture-induced inflammation with the up-regulation of integrin alpha 9. The number of corneal valves increased with the progression of inflammatory lymphangiogenesis. Moreover, we have detected lymphatic valves at various developmental stages, from incomplete to more developed ones. In addition to defining the average diameter of lymphatic vessels equipped with lymphatic valves, we also report that lymphatic valves were more often located near the branching points. Taken together, these novel findings not only provide new insights into corneal lymphatic formation and maturation, but also identify a new model for future investigation on lymphatic valve formation and possibly therapeutic intervention.Tan TruongEda AltiokDon YuenTatiana EcoiffierLu ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21918 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tan Truong Eda Altiok Don Yuen Tatiana Ecoiffier Lu Chen Novel characterization of lymphatic valve formation during corneal inflammation.
description	Lymphatic research has progressed rapidly in recent years. Though lymphatic dysfunction has been found in a wide array of disorders from transplant rejection to cancer metastasis, to date, there is still little effective treatment for lymphatic diseases. The cornea offers an optimal site for lymphatic research due to its accessible location, transparent nature, and lymphatic-free but inducible features. However, it still remains unknown whether lymphatic valves exist in newly formed lymphatic vessels in the cornea, and how this relates to an inflammatory response. In this study, we provide the first evidence showing that lymphatic valves were formed in mouse cornea during suture-induced inflammation with the up-regulation of integrin alpha 9. The number of corneal valves increased with the progression of inflammatory lymphangiogenesis. Moreover, we have detected lymphatic valves at various developmental stages, from incomplete to more developed ones. In addition to defining the average diameter of lymphatic vessels equipped with lymphatic valves, we also report that lymphatic valves were more often located near the branching points. Taken together, these novel findings not only provide new insights into corneal lymphatic formation and maturation, but also identify a new model for future investigation on lymphatic valve formation and possibly therapeutic intervention.
format	article
author	Tan Truong Eda Altiok Don Yuen Tatiana Ecoiffier Lu Chen
author_facet	Tan Truong Eda Altiok Don Yuen Tatiana Ecoiffier Lu Chen
author_sort	Tan Truong
title	Novel characterization of lymphatic valve formation during corneal inflammation.
title_short	Novel characterization of lymphatic valve formation during corneal inflammation.
title_full	Novel characterization of lymphatic valve formation during corneal inflammation.
title_fullStr	Novel characterization of lymphatic valve formation during corneal inflammation.
title_full_unstemmed	Novel characterization of lymphatic valve formation during corneal inflammation.
title_sort	novel characterization of lymphatic valve formation during corneal inflammation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/05f11e30d74745028902cbad714c2875
work_keys_str_mv	AT tantruong novelcharacterizationoflymphaticvalveformationduringcornealinflammation AT edaaltiok novelcharacterizationoflymphaticvalveformationduringcornealinflammation AT donyuen novelcharacterizationoflymphaticvalveformationduringcornealinflammation AT tatianaecoiffier novelcharacterizationoflymphaticvalveformationduringcornealinflammation AT luchen novelcharacterizationoflymphaticvalveformationduringcornealinflammation
_version_	1718424269861421056

Novel characterization of lymphatic valve formation during corneal inflammation.

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