Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments

Yukari Shirakata,1 Kouki Fukuda,1 Tomoyoshi Fujita,1 Yuki Nakano,1 Hiroyuki Nomoto,2 Hidetaka Yamaji,3 Fumio Shiraga,4 Akitaka Tsujikawa1 1Department of Ophthalmology, Faculty of Medicine, Kagawa University, Miki-cho, 2Nomoto Eye Clinic, Himeji, 3Department of Ophthalmology, Shirai Eye Hospital, Mi...

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Autores principales:	Shirakata Y, Fukuda K, Fujita T, Nakano Y, Nomoto H, Yamaji H, Shiraga F, Tsujikawa A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	anti-vascular endothelial growth factor branch retinal vein occlusion internal limiting membrane peeling macular edema pars plana vitrectomy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/05f2dfcb79784d2e9a610c559ddd25e6
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spelling	oai:doaj.org-article:05f2dfcb79784d2e9a610c559ddd25e62021-12-02T01:25:58ZPars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments1177-5483https://doaj.org/article/05f2dfcb79784d2e9a610c559ddd25e62016-02-01T00:00:00Zhttps://www.dovepress.com/pars-plana-vitrectomy-combined-with-internal-limiting-membrane-peeling-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yukari Shirakata,1 Kouki Fukuda,1 Tomoyoshi Fujita,1 Yuki Nakano,1 Hiroyuki Nomoto,2 Hidetaka Yamaji,3 Fumio Shiraga,4 Akitaka Tsujikawa1 1Department of Ophthalmology, Faculty of Medicine, Kagawa University, Miki-cho, 2Nomoto Eye Clinic, Himeji, 3Department of Ophthalmology, Shirai Eye Hospital, Mitoyo, 4Department of Ophthalmology, Okayama University, Okayama, Japan Purpose: To evaluate the anatomic and functional outcomes of pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema (ME) due to branch retinal vein occlusion (BRVO) after intravitreal injections of antivascular endothelial growth factor (anti-VEGF) agents. Methods: Twenty-four eyes of 24 patients with treatment-naive ME from BRVO were treated with intravitreal injections of anti-VEGF agents. Recurred ME was treated with pars plana vitrectomy combined with internal limiting membrane peeling. Results: After the surgery, ME was significantly reduced at 1 month (P=0.031) and the reduction increased with time (P=0.007 at the final visit). With the reduction in ME, treated eyes showed a slow improvement in visual acuity (VA). At the final visit, improvement in VA was statistically significant compared with baseline (P=0.048). The initial presence of cystoid spaces, serous retinal detachment, or subretinal hemorrhage under the fovea, as well as retinal perfusion status, showed no association with VA improvement. However, the presence of epiretinal membrane showed a significant association with the visual recovery. Although eyes without epiretinal membrane showed visual improvement (-0.10±0.32 in logarithm of the minimum angle of resolution [logMAR]), eyes with epiretinal membrane showed greater visual improvement (-0.38±0.12 in logMAR, P=0.012). Conclusion: For recurrent ME due to BRVO after anti-VEGF treatment, particularly when accompanied by epiretinal membrane, pars plana vitrectomy combined with internal limiting membrane peeling might be a possible treatment option. Keywords: antivascular endothelial growth factor, branch retinal vein occlusion, internal limiting membrane peeling, macular edema, pars plana vitrectomyShirakata YFukuda KFujita TNakano YNomoto HYamaji HShiraga FTsujikawa ADove Medical Pressarticleanti-vascular endothelial growth factorbranch retinal vein occlusioninternal limiting membrane peelingmacular edemapars plana vitrectomyOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 277-283 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-vascular endothelial growth factor branch retinal vein occlusion internal limiting membrane peeling macular edema pars plana vitrectomy Ophthalmology RE1-994
spellingShingle	anti-vascular endothelial growth factor branch retinal vein occlusion internal limiting membrane peeling macular edema pars plana vitrectomy Ophthalmology RE1-994 Shirakata Y Fukuda K Fujita T Nakano Y Nomoto H Yamaji H Shiraga F Tsujikawa A Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
description	Yukari Shirakata,1 Kouki Fukuda,1 Tomoyoshi Fujita,1 Yuki Nakano,1 Hiroyuki Nomoto,2 Hidetaka Yamaji,3 Fumio Shiraga,4 Akitaka Tsujikawa1 1Department of Ophthalmology, Faculty of Medicine, Kagawa University, Miki-cho, 2Nomoto Eye Clinic, Himeji, 3Department of Ophthalmology, Shirai Eye Hospital, Mitoyo, 4Department of Ophthalmology, Okayama University, Okayama, Japan Purpose: To evaluate the anatomic and functional outcomes of pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema (ME) due to branch retinal vein occlusion (BRVO) after intravitreal injections of antivascular endothelial growth factor (anti-VEGF) agents. Methods: Twenty-four eyes of 24 patients with treatment-naive ME from BRVO were treated with intravitreal injections of anti-VEGF agents. Recurred ME was treated with pars plana vitrectomy combined with internal limiting membrane peeling. Results: After the surgery, ME was significantly reduced at 1 month (P=0.031) and the reduction increased with time (P=0.007 at the final visit). With the reduction in ME, treated eyes showed a slow improvement in visual acuity (VA). At the final visit, improvement in VA was statistically significant compared with baseline (P=0.048). The initial presence of cystoid spaces, serous retinal detachment, or subretinal hemorrhage under the fovea, as well as retinal perfusion status, showed no association with VA improvement. However, the presence of epiretinal membrane showed a significant association with the visual recovery. Although eyes without epiretinal membrane showed visual improvement (-0.10±0.32 in logarithm of the minimum angle of resolution [logMAR]), eyes with epiretinal membrane showed greater visual improvement (-0.38±0.12 in logMAR, P=0.012). Conclusion: For recurrent ME due to BRVO after anti-VEGF treatment, particularly when accompanied by epiretinal membrane, pars plana vitrectomy combined with internal limiting membrane peeling might be a possible treatment option. Keywords: antivascular endothelial growth factor, branch retinal vein occlusion, internal limiting membrane peeling, macular edema, pars plana vitrectomy
format	article
author	Shirakata Y Fukuda K Fujita T Nakano Y Nomoto H Yamaji H Shiraga F Tsujikawa A
author_facet	Shirakata Y Fukuda K Fujita T Nakano Y Nomoto H Yamaji H Shiraga F Tsujikawa A
author_sort	Shirakata Y
title	Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
title_short	Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
title_full	Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
title_fullStr	Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
title_full_unstemmed	Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
title_sort	pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/05f2dfcb79784d2e9a610c559ddd25e6
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Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments

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