Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years

Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex karyotypes show a gradual increase of nucleotide- a...

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Autores principales:	Jakob Hofvander, Björn Viklund, Anders Isaksson, Otte Brosjö, Fredrik Vult von Steyern, Pehr Rissler, Nils Mandahl, Fredrik Mertens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05f473e7440244ce962db1231be2efa6
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spelling	oai:doaj.org-article:05f473e7440244ce962db1231be2efa62021-12-02T17:31:57ZDifferent patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years10.1038/s41467-018-06098-02041-1723https://doaj.org/article/05f473e7440244ce962db1231be2efa62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06098-0https://doaj.org/toc/2041-1723Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex karyotypes show a gradual increase of nucleotide- and chromosome-level mutations.Jakob HofvanderBjörn ViklundAnders IsakssonOtte BrosjöFredrik Vult von SteyernPehr RisslerNils MandahlFredrik MertensNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jakob Hofvander Björn Viklund Anders Isaksson Otte Brosjö Fredrik Vult von Steyern Pehr Rissler Nils Mandahl Fredrik Mertens Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
description	Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex karyotypes show a gradual increase of nucleotide- and chromosome-level mutations.
format	article
author	Jakob Hofvander Björn Viklund Anders Isaksson Otte Brosjö Fredrik Vult von Steyern Pehr Rissler Nils Mandahl Fredrik Mertens
author_facet	Jakob Hofvander Björn Viklund Anders Isaksson Otte Brosjö Fredrik Vult von Steyern Pehr Rissler Nils Mandahl Fredrik Mertens
author_sort	Jakob Hofvander
title	Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
title_short	Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
title_full	Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
title_fullStr	Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
title_full_unstemmed	Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
title_sort	different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/05f473e7440244ce962db1231be2efa6
work_keys_str_mv	AT jakobhofvander differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT bjornviklund differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT andersisaksson differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT ottebrosjo differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT fredrikvultvonsteyern differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT pehrrissler differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT nilsmandahl differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years AT fredrikmertens differentpatternsofclonalevolutionamongdifferentsarcomasubtypesfollowedforupto25years
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Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years

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