Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

Melanoma is a cancer that responds relatively well to immunotherapy but resistance does ensue. Here, the authors show that loss of IFNGR2 or JAK1 in a melanoma cell line enhances T cell mediated lysis, however these cells are paradoxically more sensitive to immune-mediated tumor control in vivo due...

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Autores principales:	Jason B. Williams, Shuyin Li, Emily F. Higgs, Alexandra Cabanov, Xiaozhong Wang, Haochu Huang, Thomas F. Gajewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05f527948e2246e587a6a28eb959a7ed
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spelling	oai:doaj.org-article:05f527948e2246e587a6a28eb959a7ed2021-12-02T16:49:44ZTumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells10.1038/s41467-020-14290-42041-1723https://doaj.org/article/05f527948e2246e587a6a28eb959a7ed2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14290-4https://doaj.org/toc/2041-1723Melanoma is a cancer that responds relatively well to immunotherapy but resistance does ensue. Here, the authors show that loss of IFNGR2 or JAK1 in a melanoma cell line enhances T cell mediated lysis, however these cells are paradoxically more sensitive to immune-mediated tumor control in vivo due to the loss of PD-L1.Jason B. WilliamsShuyin LiEmily F. HiggsAlexandra CabanovXiaozhong WangHaochu HuangThomas F. GajewskiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason B. Williams Shuyin Li Emily F. Higgs Alexandra Cabanov Xiaozhong Wang Haochu Huang Thomas F. Gajewski Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
description	Melanoma is a cancer that responds relatively well to immunotherapy but resistance does ensue. Here, the authors show that loss of IFNGR2 or JAK1 in a melanoma cell line enhances T cell mediated lysis, however these cells are paradoxically more sensitive to immune-mediated tumor control in vivo due to the loss of PD-L1.
format	article
author	Jason B. Williams Shuyin Li Emily F. Higgs Alexandra Cabanov Xiaozhong Wang Haochu Huang Thomas F. Gajewski
author_facet	Jason B. Williams Shuyin Li Emily F. Higgs Alexandra Cabanov Xiaozhong Wang Haochu Huang Thomas F. Gajewski
author_sort	Jason B. Williams
title	Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
title_short	Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
title_full	Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
title_fullStr	Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
title_full_unstemmed	Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
title_sort	tumor heterogeneity and clonal cooperation influence the immune selection of ifn-γ-signaling mutant cancer cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/05f527948e2246e587a6a28eb959a7ed
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Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells

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