Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
Melanoma is a cancer that responds relatively well to immunotherapy but resistance does ensue. Here, the authors show that loss of IFNGR2 or JAK1 in a melanoma cell line enhances T cell mediated lysis, however these cells are paradoxically more sensitive to immune-mediated tumor control in vivo due...
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Auteurs principaux: | Jason B. Williams, Shuyin Li, Emily F. Higgs, Alexandra Cabanov, Xiaozhong Wang, Haochu Huang, Thomas F. Gajewski |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
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Accès en ligne: | https://doaj.org/article/05f527948e2246e587a6a28eb959a7ed |
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