Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy

The antitumor activity of triptolide (TP) has received widespread attention, although its toxicity severely limits its clinical application. Therefore, the design of a targeted drug delivery system (TDDS) has important application prospects in tumor treatment. Metal–organic frameworks (MOFs), with h...

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Autores principales:	Mengru Cai, Yawen Zeng, Manting Liu, Longtai You, Huating Huang, Yang Hao, Xingbin Yin, Changhai Qu, Jian Ni, Xiaoxv Dong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MOFs targeting drug delivery cancer controlled release Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/05f5451bf34a4efbbd136073edcf3ce5
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id	oai:doaj.org-article:05f5451bf34a4efbbd136073edcf3ce5
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spelling	oai:doaj.org-article:05f5451bf34a4efbbd136073edcf3ce52021-11-25T18:42:14ZConstruction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy10.3390/pharmaceutics131119451999-4923https://doaj.org/article/05f5451bf34a4efbbd136073edcf3ce52021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1945https://doaj.org/toc/1999-4923The antitumor activity of triptolide (TP) has received widespread attention, although its toxicity severely limits its clinical application. Therefore, the design of a targeted drug delivery system (TDDS) has important application prospects in tumor treatment. Metal–organic frameworks (MOFs), with high drug-carrying capacity and good biocompatibility, have aroused widespread interest for drug delivery systems. Herein, folic acid (FA) and 5-carboxylic acid fluorescein (5-FAM) were used to modify Fe-MIL-101 to construct a functionalized nano-platform (5-FAM/FA/TP@Fe-MIL-101) for the targeted delivery of the anti-tumor drug triptolide and realize in vivo fluorescence imaging. Compared with Fe-MIL-101, functionalized nanoparticles not only showed better targeted therapy efficiency, but also reduced the systemic toxicity of triptolide. In addition, the modification of 5-FAM facilitated fluorescence imaging of the tumor site and realized the construction of an integrated nano-platform for fluorescence imaging and treatment. Both in vitro and in vivo studies of functionalized nanoparticles have demonstrated excellent fluorescence imaging and synergistic targeting anticancer activity with negligible systemic toxicity. The development of functional nano-platform provides new ideas for the design of MOF-based multifunctional nano-drug delivery system, which can be used for precise treatment of tumor.Mengru CaiYawen ZengManting LiuLongtai YouHuating HuangYang HaoXingbin YinChanghai QuJian NiXiaoxv DongMDPI AGarticleMOFstargeting drug deliverycancercontrolled releasePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1945, p 1945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MOFs targeting drug delivery cancer controlled release Pharmacy and materia medica RS1-441
spellingShingle	MOFs targeting drug delivery cancer controlled release Pharmacy and materia medica RS1-441 Mengru Cai Yawen Zeng Manting Liu Longtai You Huating Huang Yang Hao Xingbin Yin Changhai Qu Jian Ni Xiaoxv Dong Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy
description	The antitumor activity of triptolide (TP) has received widespread attention, although its toxicity severely limits its clinical application. Therefore, the design of a targeted drug delivery system (TDDS) has important application prospects in tumor treatment. Metal–organic frameworks (MOFs), with high drug-carrying capacity and good biocompatibility, have aroused widespread interest for drug delivery systems. Herein, folic acid (FA) and 5-carboxylic acid fluorescein (5-FAM) were used to modify Fe-MIL-101 to construct a functionalized nano-platform (5-FAM/FA/TP@Fe-MIL-101) for the targeted delivery of the anti-tumor drug triptolide and realize in vivo fluorescence imaging. Compared with Fe-MIL-101, functionalized nanoparticles not only showed better targeted therapy efficiency, but also reduced the systemic toxicity of triptolide. In addition, the modification of 5-FAM facilitated fluorescence imaging of the tumor site and realized the construction of an integrated nano-platform for fluorescence imaging and treatment. Both in vitro and in vivo studies of functionalized nanoparticles have demonstrated excellent fluorescence imaging and synergistic targeting anticancer activity with negligible systemic toxicity. The development of functional nano-platform provides new ideas for the design of MOF-based multifunctional nano-drug delivery system, which can be used for precise treatment of tumor.
format	article
author	Mengru Cai Yawen Zeng Manting Liu Longtai You Huating Huang Yang Hao Xingbin Yin Changhai Qu Jian Ni Xiaoxv Dong
author_facet	Mengru Cai Yawen Zeng Manting Liu Longtai You Huating Huang Yang Hao Xingbin Yin Changhai Qu Jian Ni Xiaoxv Dong
author_sort	Mengru Cai
title	Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy
title_short	Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy
title_full	Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy
title_fullStr	Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy
title_full_unstemmed	Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy
title_sort	construction of a multifunctional nano-scale metal-organic framework-based drug delivery system for targeted cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/05f5451bf34a4efbbd136073edcf3ce5
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Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy

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