Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.

<h4>Objective</h4>Sepsis is an inflammatory syndrome caused by infection, and both its incidence and mortality are high. Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with se...

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Autores principales:	Ding Wang, Xuan Zhong, Dongjian Huang, Rui Chen, Guibin Bai, Qing Li, Bolan Yu, Yong Fan, Xiaofang Sun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05f63d417c634beeafed29b76ce0abfe
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spelling	oai:doaj.org-article:05f63d417c634beeafed29b76ce0abfe2021-11-18T08:35:50ZFunctional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.1932-620310.1371/journal.pone.0087049https://doaj.org/article/05f63d417c634beeafed29b76ce0abfe2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24475220/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Sepsis is an inflammatory syndrome caused by infection, and both its incidence and mortality are high. Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with sepsis.<h4>Methods</h4>A total of 196 patients with pneumonia-induced sepsis and 213 age- and sex-matched healthy volunteers participated in our study from July 2012 to July 2013 in Guangzhou, China. Patient clinical information was collected. Clinical pathology was assessed in subgroups defined based on clinical criteria, APACHE II (acute physiology and chronic health evaluation) and SOFA (sepsis-related organ failure assessment) scores and discharge rate. Four functional SNPs, -1616T/C (rs2069705), -764G/C (rs2069707), +874A/T (rs2430561) and +3234C/T (rs2069718), were genotyped by Snapshot in both sepsis patients and healthy controls. Pearson's chi-square test or Fisher's exact test were used to analyze the distribution of the SNPs, and the probability values (P values), odds ratios (OR) and 95% confidence intervals (CIs) were calculated.<h4>Results</h4>No mutations in the IFN-γ -764G/C SNP were detected among the participants in our study. The +874A/T and +3234C/T SNPs were in strong linkage disequilibrium (LD) (r(2) = 0.894). The -1616 TC+TT, +874 AT+AA genotype and the TAC haplotype were significantly associated with sepsis susceptibility, while the CTT haplotype was associated with protection against sepsis incidence. Genotype of -1616 TT wasn't only protective against severity of sepsis, but also against higher APACHE II and SOFA scores as +874 AA and +3234 CC. The TAC haplotype was was protective against progression to severe sepsis either.<h4>Conclusion</h4>Our results suggest that functional IFN-γ SNPs and their haplotypes are associated with pneumonia-induced sepsis.Ding WangXuan ZhongDongjian HuangRui ChenGuibin BaiQing LiBolan YuYong FanXiaofang SunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87049 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ding Wang Xuan Zhong Dongjian Huang Rui Chen Guibin Bai Qing Li Bolan Yu Yong Fan Xiaofang Sun Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
description	<h4>Objective</h4>Sepsis is an inflammatory syndrome caused by infection, and both its incidence and mortality are high. Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with sepsis.<h4>Methods</h4>A total of 196 patients with pneumonia-induced sepsis and 213 age- and sex-matched healthy volunteers participated in our study from July 2012 to July 2013 in Guangzhou, China. Patient clinical information was collected. Clinical pathology was assessed in subgroups defined based on clinical criteria, APACHE II (acute physiology and chronic health evaluation) and SOFA (sepsis-related organ failure assessment) scores and discharge rate. Four functional SNPs, -1616T/C (rs2069705), -764G/C (rs2069707), +874A/T (rs2430561) and +3234C/T (rs2069718), were genotyped by Snapshot in both sepsis patients and healthy controls. Pearson's chi-square test or Fisher's exact test were used to analyze the distribution of the SNPs, and the probability values (P values), odds ratios (OR) and 95% confidence intervals (CIs) were calculated.<h4>Results</h4>No mutations in the IFN-γ -764G/C SNP were detected among the participants in our study. The +874A/T and +3234C/T SNPs were in strong linkage disequilibrium (LD) (r(2) = 0.894). The -1616 TC+TT, +874 AT+AA genotype and the TAC haplotype were significantly associated with sepsis susceptibility, while the CTT haplotype was associated with protection against sepsis incidence. Genotype of -1616 TT wasn't only protective against severity of sepsis, but also against higher APACHE II and SOFA scores as +874 AA and +3234 CC. The TAC haplotype was was protective against progression to severe sepsis either.<h4>Conclusion</h4>Our results suggest that functional IFN-γ SNPs and their haplotypes are associated with pneumonia-induced sepsis.
format	article
author	Ding Wang Xuan Zhong Dongjian Huang Rui Chen Guibin Bai Qing Li Bolan Yu Yong Fan Xiaofang Sun
author_facet	Ding Wang Xuan Zhong Dongjian Huang Rui Chen Guibin Bai Qing Li Bolan Yu Yong Fan Xiaofang Sun
author_sort	Ding Wang
title	Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
title_short	Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
title_full	Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
title_fullStr	Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
title_full_unstemmed	Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
title_sort	functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/05f63d417c634beeafed29b76ce0abfe
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Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.

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