Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center
Background. The incidence and burden of arrhythmias in myocarditis are under-reported. Objective. We aimed to assess the diagnostic yield and clinical impact of continuous arrhythmia monitoring (CAM) in patients with arrhythmic myocarditis. Methods. We enrolled consecutive adult patients (<i>n...
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2021
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oai:doaj.org-article:05fada0fdce049a0a8d42f4f8d28171b2021-11-11T17:45:54ZContinuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center10.3390/jcm102151422077-0383https://doaj.org/article/05fada0fdce049a0a8d42f4f8d28171b2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5142https://doaj.org/toc/2077-0383Background. The incidence and burden of arrhythmias in myocarditis are under-reported. Objective. We aimed to assess the diagnostic yield and clinical impact of continuous arrhythmia monitoring (CAM) in patients with arrhythmic myocarditis. Methods. We enrolled consecutive adult patients (<i>n</i> = 104; 71% males, age 47 ± 11 year, mean LVEF 50 ± 13%) with biopsy-proven active myocarditis and de novo ventricular arrhythmias (VAs). All patients underwent prospective monitoring by both sequential 24-h Holter ECGs and CAM, including either ICD (<i>n</i> = 62; 60%) or loop recorder (<i>n</i> = 42; 40%). Results. By 3.7 ± 1.6 year follow up, 45 patients (43%) had VT, 67 (64%) NSVT and 102 (98%) premature ventricular complexes (PVC). As compared to the Holter ECG (average 9.5 exams per patient), CAM identified more patients with VA (VT: 45 vs. 4; NSVT: 64 vs. 45; both <i>p</i> < 0.001), more VA episodes (VT: 100 vs. 4%; NSVT: 91 vs. 12%) and earlier NSVT timing (median 6 vs. 24 months, <i>p</i> < 0.001). The extensive ICD implantation strategy was proven beneficial in 80% of the population. Histological signs of chronically active myocarditis (<i>n</i> = 73, 70%) and anteroseptal late gadolinium enhancement (<i>n</i> = 26, 25%) were significantly associated with the occurrence of VTs during follow up, even in the primary prevention subgroup. Conclusion. In patients with arrhythmic myocarditis, CAM allowed accurate arrhythmia detection and showed a considerable clinical impact.Giovanni PerettoPatrizio MazzoneGabriele PaglinoAlessandra MarziGeorgios TsitsinakisStefania RizzoCristina BassoPaolo Della BellaSimone SalaMDPI AGarticlemyocarditisarrhythmiastelemonitoringimplantable cardioverter defibrillatorimplantable loop recorderHolter ECGMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5142, p 5142 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
myocarditis arrhythmias telemonitoring implantable cardioverter defibrillator implantable loop recorder Holter ECG Medicine R |
| spellingShingle |
myocarditis arrhythmias telemonitoring implantable cardioverter defibrillator implantable loop recorder Holter ECG Medicine R Giovanni Peretto Patrizio Mazzone Gabriele Paglino Alessandra Marzi Georgios Tsitsinakis Stefania Rizzo Cristina Basso Paolo Della Bella Simone Sala Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center |
| description |
Background. The incidence and burden of arrhythmias in myocarditis are under-reported. Objective. We aimed to assess the diagnostic yield and clinical impact of continuous arrhythmia monitoring (CAM) in patients with arrhythmic myocarditis. Methods. We enrolled consecutive adult patients (<i>n</i> = 104; 71% males, age 47 ± 11 year, mean LVEF 50 ± 13%) with biopsy-proven active myocarditis and de novo ventricular arrhythmias (VAs). All patients underwent prospective monitoring by both sequential 24-h Holter ECGs and CAM, including either ICD (<i>n</i> = 62; 60%) or loop recorder (<i>n</i> = 42; 40%). Results. By 3.7 ± 1.6 year follow up, 45 patients (43%) had VT, 67 (64%) NSVT and 102 (98%) premature ventricular complexes (PVC). As compared to the Holter ECG (average 9.5 exams per patient), CAM identified more patients with VA (VT: 45 vs. 4; NSVT: 64 vs. 45; both <i>p</i> < 0.001), more VA episodes (VT: 100 vs. 4%; NSVT: 91 vs. 12%) and earlier NSVT timing (median 6 vs. 24 months, <i>p</i> < 0.001). The extensive ICD implantation strategy was proven beneficial in 80% of the population. Histological signs of chronically active myocarditis (<i>n</i> = 73, 70%) and anteroseptal late gadolinium enhancement (<i>n</i> = 26, 25%) were significantly associated with the occurrence of VTs during follow up, even in the primary prevention subgroup. Conclusion. In patients with arrhythmic myocarditis, CAM allowed accurate arrhythmia detection and showed a considerable clinical impact. |
| format |
article |
| author |
Giovanni Peretto Patrizio Mazzone Gabriele Paglino Alessandra Marzi Georgios Tsitsinakis Stefania Rizzo Cristina Basso Paolo Della Bella Simone Sala |
| author_facet |
Giovanni Peretto Patrizio Mazzone Gabriele Paglino Alessandra Marzi Georgios Tsitsinakis Stefania Rizzo Cristina Basso Paolo Della Bella Simone Sala |
| author_sort |
Giovanni Peretto |
| title |
Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center |
| title_short |
Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center |
| title_full |
Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center |
| title_fullStr |
Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center |
| title_full_unstemmed |
Continuous Electrical Monitoring in Patients with Arrhythmic Myocarditis: Insights from a Referral Center |
| title_sort |
continuous electrical monitoring in patients with arrhythmic myocarditis: insights from a referral center |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/05fada0fdce049a0a8d42f4f8d28171b |
| work_keys_str_mv |
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