Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span> lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4)...
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2021
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oai:doaj.org-article:06022508313c4e0b82130604676fbff12021-11-25T18:13:34ZPreliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers10.3390/ma142267771996-1944https://doaj.org/article/06022508313c4e0b82130604676fbff12021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6777https://doaj.org/toc/1996-1944In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span> lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing.Ha-Eun ShimYeong-Heum YeonDae-Hee LimYou-Ree NamJin-Hyung ParkNam-Ho LeeHui-Jeong GwonMDPI AGarticlePLCLPLDLAchain scissiondegradationgamma-rayGeant4TechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6777, p 6777 (2021) |
institution |
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collection |
DOAJ |
language |
EN |
topic |
PLCL PLDLA chain scission degradation gamma-ray Geant4 Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 |
spellingShingle |
PLCL PLDLA chain scission degradation gamma-ray Geant4 Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Ha-Eun Shim Yeong-Heum Yeon Dae-Hee Lim You-Ree Nam Jin-Hyung Park Nam-Ho Lee Hui-Jeong Gwon Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers |
description |
In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span> lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing. |
format |
article |
author |
Ha-Eun Shim Yeong-Heum Yeon Dae-Hee Lim You-Ree Nam Jin-Hyung Park Nam-Ho Lee Hui-Jeong Gwon |
author_facet |
Ha-Eun Shim Yeong-Heum Yeon Dae-Hee Lim You-Ree Nam Jin-Hyung Park Nam-Ho Lee Hui-Jeong Gwon |
author_sort |
Ha-Eun Shim |
title |
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers |
title_short |
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers |
title_full |
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers |
title_fullStr |
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers |
title_full_unstemmed |
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers |
title_sort |
preliminary study on the simulation of a radiation damage analysis of biodegradable polymers |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/06022508313c4e0b82130604676fbff1 |
work_keys_str_mv |
AT haeunshim preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers AT yeongheumyeon preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers AT daeheelim preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers AT youreenam preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers AT jinhyungpark preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers AT namholee preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers AT huijeonggwon preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers |
_version_ |
1718411419370651648 |