Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers

In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span> lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4)...

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Autores principales: Ha-Eun Shim, Yeong-Heum Yeon, Dae-Hee Lim, You-Ree Nam, Jin-Hyung Park, Nam-Ho Lee, Hui-Jeong Gwon
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:06022508313c4e0b82130604676fbff12021-11-25T18:13:34ZPreliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers10.3390/ma142267771996-1944https://doaj.org/article/06022508313c4e0b82130604676fbff12021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6777https://doaj.org/toc/1996-1944In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span> lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing.Ha-Eun ShimYeong-Heum YeonDae-Hee LimYou-Ree NamJin-Hyung ParkNam-Ho LeeHui-Jeong GwonMDPI AGarticlePLCLPLDLAchain scissiondegradationgamma-rayGeant4TechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6777, p 6777 (2021)
institution DOAJ
collection DOAJ
language EN
topic PLCL
PLDLA
chain scission
degradation
gamma-ray
Geant4
Technology
T
Electrical engineering. Electronics. Nuclear engineering
TK1-9971
Engineering (General). Civil engineering (General)
TA1-2040
Microscopy
QH201-278.5
Descriptive and experimental mechanics
QC120-168.85
spellingShingle PLCL
PLDLA
chain scission
degradation
gamma-ray
Geant4
Technology
T
Electrical engineering. Electronics. Nuclear engineering
TK1-9971
Engineering (General). Civil engineering (General)
TA1-2040
Microscopy
QH201-278.5
Descriptive and experimental mechanics
QC120-168.85
Ha-Eun Shim
Yeong-Heum Yeon
Dae-Hee Lim
You-Ree Nam
Jin-Hyung Park
Nam-Ho Lee
Hui-Jeong Gwon
Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
description In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-<span style="font-variant: small-caps;">d</span>,<span style="font-variant: small-caps;">l</span> lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing.
format article
author Ha-Eun Shim
Yeong-Heum Yeon
Dae-Hee Lim
You-Ree Nam
Jin-Hyung Park
Nam-Ho Lee
Hui-Jeong Gwon
author_facet Ha-Eun Shim
Yeong-Heum Yeon
Dae-Hee Lim
You-Ree Nam
Jin-Hyung Park
Nam-Ho Lee
Hui-Jeong Gwon
author_sort Ha-Eun Shim
title Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_short Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_full Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_fullStr Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_full_unstemmed Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers
title_sort preliminary study on the simulation of a radiation damage analysis of biodegradable polymers
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/06022508313c4e0b82130604676fbff1
work_keys_str_mv AT haeunshim preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
AT yeongheumyeon preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
AT daeheelim preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
AT youreenam preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
AT jinhyungpark preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
AT namholee preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
AT huijeonggwon preliminarystudyonthesimulationofaradiationdamageanalysisofbiodegradablepolymers
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