Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

While ERK signalling can produce switch-like cell behaviour, phosphorylation of ERK increases linearly with extracellular signals. Here, the authors solve this seeming contradiction by showing that nuclear translocation of ERK behaves in a switch-like manner and is controlled by ERK activity.

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Autores principales:	Yuki Shindo, Kazunari Iwamoto, Kazunari Mouri, Kayo Hibino, Masaru Tomita, Hidetaka Kosako, Yasushi Sako, Koichi Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/060548370a304893a89d1d715f0dd5dd
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spelling	oai:doaj.org-article:060548370a304893a89d1d715f0dd5dd2021-12-02T17:32:21ZConversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling10.1038/ncomms104852041-1723https://doaj.org/article/060548370a304893a89d1d715f0dd5dd2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10485https://doaj.org/toc/2041-1723While ERK signalling can produce switch-like cell behaviour, phosphorylation of ERK increases linearly with extracellular signals. Here, the authors solve this seeming contradiction by showing that nuclear translocation of ERK behaves in a switch-like manner and is controlled by ERK activity.Yuki ShindoKazunari IwamotoKazunari MouriKayo HibinoMasaru TomitaHidetaka KosakoYasushi SakoKoichi TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Shindo Kazunari Iwamoto Kazunari Mouri Kayo Hibino Masaru Tomita Hidetaka Kosako Yasushi Sako Koichi Takahashi Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
description	While ERK signalling can produce switch-like cell behaviour, phosphorylation of ERK increases linearly with extracellular signals. Here, the authors solve this seeming contradiction by showing that nuclear translocation of ERK behaves in a switch-like manner and is controlled by ERK activity.
format	article
author	Yuki Shindo Kazunari Iwamoto Kazunari Mouri Kayo Hibino Masaru Tomita Hidetaka Kosako Yasushi Sako Koichi Takahashi
author_facet	Yuki Shindo Kazunari Iwamoto Kazunari Mouri Kayo Hibino Masaru Tomita Hidetaka Kosako Yasushi Sako Koichi Takahashi
author_sort	Yuki Shindo
title	Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
title_short	Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
title_full	Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
title_fullStr	Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
title_full_unstemmed	Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
title_sort	conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in erk signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/060548370a304893a89d1d715f0dd5dd
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Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

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