Impact of artificial airway resistances on regional ventilation distribution during airway closure

Electrical impedance tomography (EIT), a noninvasive and radiation-free imaging technique can be used in pulmonary function monitoring for determining regional ventilation distribution within the lung. Gold standard in pulmonary function monitoring is spirometry/body plethysmography, a method using...

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Autores principales:	März Melanie, Howe Sarah, Laufer Bernhard, Moeller Knut, Krueger-Ziolek Sabine
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	electrical impedance tomography airway obstructions artificial airway resistance regional ventilation distribution body plethysmography Medicine R
Acceso en línea:	https://doaj.org/article/060691330944439cbc0db57e81493505
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spelling	oai:doaj.org-article:060691330944439cbc0db57e814935052021-12-05T14:10:42ZImpact of artificial airway resistances on regional ventilation distribution during airway closure2364-550410.1515/cdbme-2020-3009https://doaj.org/article/060691330944439cbc0db57e814935052020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3009https://doaj.org/toc/2364-5504Electrical impedance tomography (EIT), a noninvasive and radiation-free imaging technique can be used in pulmonary function monitoring for determining regional ventilation distribution within the lung. Gold standard in pulmonary function monitoring is spirometry/body plethysmography, a method using forced breathing maneuvers to obtain global lung function parameters. However, this method is heavily dependent on the cooperation of the patients. Within this observational study, a method under normal breathing was tested with 5 healthy volunteers, which provides regional information about ventilation distribution. The occlusion method Rocc, a method for determining airway resistance, was used to create a short-term airway closure. Regional ventilation during the airway closure was examined with EIT. Simultaneously four different artificial airway resistances were used to simulate airway obstructions. Results show that EIT in combination with the ROcc method is suitable for the detection of regional differences in ventilation during airway closure for all four artificial airway resistances. Although the sum of relative impedances at the end of the shutter maneuver are smaller (nearly -0.100 AU) for the airway resistances Ø 12.5 mm, Ø 10.5 mm and Ø 9.5 mm than for the smallest one with Ø 30.0 mm (~ -0.070 AU), the changes in impedance from the start to the end of the shutter maneuver differs only slightly between the four artificial airway resistances. All impedance changes are in the range of 0.100 to 0.130 AU. The combination of EIT and the ROcc method provides not only global parameters such as airway resistance under normal breathing conditions, but also results of regional ventilation, which could enable the identification of areas affected by airway obstructions. However, the obtained results indicate that EIT might be a useful tool in the diagnosis and follow-up of obstructive lung diseases.März MelanieHowe SarahLaufer BernhardMoeller KnutKrueger-Ziolek SabineDe Gruyterarticleelectrical impedance tomographyairway obstructionsartificial airway resistanceregional ventilation distributionbody plethysmographyMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 32-35 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrical impedance tomography airway obstructions artificial airway resistance regional ventilation distribution body plethysmography Medicine R
spellingShingle	electrical impedance tomography airway obstructions artificial airway resistance regional ventilation distribution body plethysmography Medicine R März Melanie Howe Sarah Laufer Bernhard Moeller Knut Krueger-Ziolek Sabine Impact of artificial airway resistances on regional ventilation distribution during airway closure
description	Electrical impedance tomography (EIT), a noninvasive and radiation-free imaging technique can be used in pulmonary function monitoring for determining regional ventilation distribution within the lung. Gold standard in pulmonary function monitoring is spirometry/body plethysmography, a method using forced breathing maneuvers to obtain global lung function parameters. However, this method is heavily dependent on the cooperation of the patients. Within this observational study, a method under normal breathing was tested with 5 healthy volunteers, which provides regional information about ventilation distribution. The occlusion method Rocc, a method for determining airway resistance, was used to create a short-term airway closure. Regional ventilation during the airway closure was examined with EIT. Simultaneously four different artificial airway resistances were used to simulate airway obstructions. Results show that EIT in combination with the ROcc method is suitable for the detection of regional differences in ventilation during airway closure for all four artificial airway resistances. Although the sum of relative impedances at the end of the shutter maneuver are smaller (nearly -0.100 AU) for the airway resistances Ø 12.5 mm, Ø 10.5 mm and Ø 9.5 mm than for the smallest one with Ø 30.0 mm (~ -0.070 AU), the changes in impedance from the start to the end of the shutter maneuver differs only slightly between the four artificial airway resistances. All impedance changes are in the range of 0.100 to 0.130 AU. The combination of EIT and the ROcc method provides not only global parameters such as airway resistance under normal breathing conditions, but also results of regional ventilation, which could enable the identification of areas affected by airway obstructions. However, the obtained results indicate that EIT might be a useful tool in the diagnosis and follow-up of obstructive lung diseases.
format	article
author	März Melanie Howe Sarah Laufer Bernhard Moeller Knut Krueger-Ziolek Sabine
author_facet	März Melanie Howe Sarah Laufer Bernhard Moeller Knut Krueger-Ziolek Sabine
author_sort	März Melanie
title	Impact of artificial airway resistances on regional ventilation distribution during airway closure
title_short	Impact of artificial airway resistances on regional ventilation distribution during airway closure
title_full	Impact of artificial airway resistances on regional ventilation distribution during airway closure
title_fullStr	Impact of artificial airway resistances on regional ventilation distribution during airway closure
title_full_unstemmed	Impact of artificial airway resistances on regional ventilation distribution during airway closure
title_sort	impact of artificial airway resistances on regional ventilation distribution during airway closure
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/060691330944439cbc0db57e81493505
work_keys_str_mv	AT marzmelanie impactofartificialairwayresistancesonregionalventilationdistributionduringairwayclosure AT howesarah impactofartificialairwayresistancesonregionalventilationdistributionduringairwayclosure AT lauferbernhard impactofartificialairwayresistancesonregionalventilationdistributionduringairwayclosure AT moellerknut impactofartificialairwayresistancesonregionalventilationdistributionduringairwayclosure AT kruegerzioleksabine impactofartificialairwayresistancesonregionalventilationdistributionduringairwayclosure
_version_	1718371820187418624

Impact of artificial airway resistances on regional ventilation distribution during airway closure

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