Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data

Plaque psoriasis (PSO) and lichen planus (LP) are skin diseases with some similarities in pathogenesis, comorbidities, and clinical presentation. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and its ligand, α<sub>4</sub>β<sub>7</sub> integrin, are involved in inflamm...

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Autores principales:	Anna Baran, Julia Nowowiejska, Tomasz W. Kamiński, Julita A. Krahel, Iwona Flisiak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psoriasis lichen planus α<sub>4</sub>β<sub>7</sub> integrin MAdCAM-1 ITGB7 mucosal addressin cell adhesion molecule-1 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/060788058e9c4fc49ee3f56cccaea6ae
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spelling	oai:doaj.org-article:060788058e9c4fc49ee3f56cccaea6ae2021-11-25T16:47:15ZCirculating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data10.3390/biology101111292079-7737https://doaj.org/article/060788058e9c4fc49ee3f56cccaea6ae2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1129https://doaj.org/toc/2079-7737Plaque psoriasis (PSO) and lichen planus (LP) are skin diseases with some similarities in pathogenesis, comorbidities, and clinical presentation. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and its ligand, α<sub>4</sub>β<sub>7</sub> integrin, are involved in inflammatory bowel diseases and liver dysfunctions, which occur more frequently in PSO and LP. Serum MAdCAM-1 and ITGB7 levels in patients with plaque PSO and eruptive LP have never been studied before. The study included 42 patients with PSO, 13 with LP, and 23 controls. Serum molecules levels were evaluated using the immune–enzymatic method. ITGB7 concentration was not statistically different, both in patients with PSO and LP, compared to controls (both <i>p</i> > 0.05). MAdCAM-1 level was significantly lower in PSO subjects than in controls (<i>p</i> = 0.041), whereas in the LP group, a downward trend was observed (<i>p</i> = 0.088) with <i>p</i> = 0.0455 in ANOVA. Multiple linear regression revealed independent associations between ITGB7 and HDL and BMI and RBC in the LP group. In psoriatic patients with elevated CRP, there was an upward trend for MAdCAM-1, and also a positive correlation between MAdCAM-1 and WBC. ITGB7 and MAdCAM-1 cannot serve as markers of disease activity or liver pathology neither in patients with PSO nor LP. MAdCAM-1 might play a role as an inflammation indicator in PSO and a beneficial influence on the lipid profile in LP.Anna BaranJulia NowowiejskaTomasz W. KamińskiJulita A. KrahelIwona FlisiakMDPI AGarticlepsoriasislichen planusα<sub>4</sub>β<sub>7</sub> integrinMAdCAM-1ITGB7mucosal addressin cell adhesion molecule-1Biology (General)QH301-705.5ENBiology, Vol 10, Iss 1129, p 1129 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis lichen planus α<sub>4</sub>β<sub>7</sub> integrin MAdCAM-1 ITGB7 mucosal addressin cell adhesion molecule-1 Biology (General) QH301-705.5
spellingShingle	psoriasis lichen planus α<sub>4</sub>β<sub>7</sub> integrin MAdCAM-1 ITGB7 mucosal addressin cell adhesion molecule-1 Biology (General) QH301-705.5 Anna Baran Julia Nowowiejska Tomasz W. Kamiński Julita A. Krahel Iwona Flisiak Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
description	Plaque psoriasis (PSO) and lichen planus (LP) are skin diseases with some similarities in pathogenesis, comorbidities, and clinical presentation. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and its ligand, α<sub>4</sub>β<sub>7</sub> integrin, are involved in inflammatory bowel diseases and liver dysfunctions, which occur more frequently in PSO and LP. Serum MAdCAM-1 and ITGB7 levels in patients with plaque PSO and eruptive LP have never been studied before. The study included 42 patients with PSO, 13 with LP, and 23 controls. Serum molecules levels were evaluated using the immune–enzymatic method. ITGB7 concentration was not statistically different, both in patients with PSO and LP, compared to controls (both <i>p</i> > 0.05). MAdCAM-1 level was significantly lower in PSO subjects than in controls (<i>p</i> = 0.041), whereas in the LP group, a downward trend was observed (<i>p</i> = 0.088) with <i>p</i> = 0.0455 in ANOVA. Multiple linear regression revealed independent associations between ITGB7 and HDL and BMI and RBC in the LP group. In psoriatic patients with elevated CRP, there was an upward trend for MAdCAM-1, and also a positive correlation between MAdCAM-1 and WBC. ITGB7 and MAdCAM-1 cannot serve as markers of disease activity or liver pathology neither in patients with PSO nor LP. MAdCAM-1 might play a role as an inflammation indicator in PSO and a beneficial influence on the lipid profile in LP.
format	article
author	Anna Baran Julia Nowowiejska Tomasz W. Kamiński Julita A. Krahel Iwona Flisiak
author_facet	Anna Baran Julia Nowowiejska Tomasz W. Kamiński Julita A. Krahel Iwona Flisiak
author_sort	Anna Baran
title	Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
title_short	Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
title_full	Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
title_fullStr	Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
title_full_unstemmed	Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
title_sort	circulating madcam-1 and itgb7 in patients with plaque psoriasis and eruptive lichen planus—preliminary data
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/060788058e9c4fc49ee3f56cccaea6ae
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Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data

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