Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis

Tympanic membrane (TM) is vulnerable to a variety of middle ear diseases. In some cases, reconstruction or repair of the TM is essential for recovering the hearing. Although there are many kinds of materials and therapeutics for TM reconstruction, tissue engineering of the TM is still in its initial...

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Autores principales:	Ali A. Rostam-Alilou, Hamid Jafari, Ali Zolfagharian, Ahmad Serjouei, Mahdi Bodaghi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Tympanic membrane graft Vibro-acoustic analysis Bio-inspired design Composite hydrogels Silk biomaterial Spider web Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/0607c4d26f78427dba31ec10cae54d75
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id	oai:doaj.org-article:0607c4d26f78427dba31ec10cae54d75
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spelling	oai:doaj.org-article:0607c4d26f78427dba31ec10cae54d752021-11-12T04:48:39ZUsing fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis2666-682010.1016/j.jcomc.2021.100205https://doaj.org/article/0607c4d26f78427dba31ec10cae54d752021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666682021000980https://doaj.org/toc/2666-6820Tympanic membrane (TM) is vulnerable to a variety of middle ear diseases. In some cases, reconstruction or repair of the TM is essential for recovering the hearing. Although there are many kinds of materials and therapeutics for TM reconstruction, tissue engineering of the TM is still in its initial steps of advancement. Treatment of damaged TM is usually carried out by otology-related techniques such as myringoplasty and tympanoplasty. Most of the novel tympanoplasty methods employ artificial grafts made of biomaterials and polymers for scaffolds. One biomaterial candidate for design and fabrication of synthetic grafts is spider silk, which has excellent mechanical and acoustic characteristics. On the other hand, the structural function of the spider web is also one of the potential inspirations for designing tissue-engineered grafts on micro-scale explorations. In this study, a bio-inspired design and analysis of silky TM grafts are carried out employing finite element modeling and vibro-acoustic investigation. A comparative and statistical analysis is also performed with experimentally validated data to check the suitability of the materials and design. The numerical study shows that the proposed bio-inspired models are appropriate for TM graft design and fabrication. The effects of inspired architecture and materials on obtaining an optimum design for TM grafts are put into evidence via a parametric study, and pertinent conclusions are outlined.Ali A. Rostam-AlilouHamid JafariAli ZolfagharianAhmad SerjoueiMahdi BodaghiElsevierarticleTympanic membrane graftVibro-acoustic analysisBio-inspired designComposite hydrogelsSilk biomaterialSpider webMaterials of engineering and construction. Mechanics of materialsTA401-492ENComposites Part C: Open Access, Vol 6, Iss , Pp 100205- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tympanic membrane graft Vibro-acoustic analysis Bio-inspired design Composite hydrogels Silk biomaterial Spider web Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Tympanic membrane graft Vibro-acoustic analysis Bio-inspired design Composite hydrogels Silk biomaterial Spider web Materials of engineering and construction. Mechanics of materials TA401-492 Ali A. Rostam-Alilou Hamid Jafari Ali Zolfagharian Ahmad Serjouei Mahdi Bodaghi Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis
description	Tympanic membrane (TM) is vulnerable to a variety of middle ear diseases. In some cases, reconstruction or repair of the TM is essential for recovering the hearing. Although there are many kinds of materials and therapeutics for TM reconstruction, tissue engineering of the TM is still in its initial steps of advancement. Treatment of damaged TM is usually carried out by otology-related techniques such as myringoplasty and tympanoplasty. Most of the novel tympanoplasty methods employ artificial grafts made of biomaterials and polymers for scaffolds. One biomaterial candidate for design and fabrication of synthetic grafts is spider silk, which has excellent mechanical and acoustic characteristics. On the other hand, the structural function of the spider web is also one of the potential inspirations for designing tissue-engineered grafts on micro-scale explorations. In this study, a bio-inspired design and analysis of silky TM grafts are carried out employing finite element modeling and vibro-acoustic investigation. A comparative and statistical analysis is also performed with experimentally validated data to check the suitability of the materials and design. The numerical study shows that the proposed bio-inspired models are appropriate for TM graft design and fabrication. The effects of inspired architecture and materials on obtaining an optimum design for TM grafts are put into evidence via a parametric study, and pertinent conclusions are outlined.
format	article
author	Ali A. Rostam-Alilou Hamid Jafari Ali Zolfagharian Ahmad Serjouei Mahdi Bodaghi
author_facet	Ali A. Rostam-Alilou Hamid Jafari Ali Zolfagharian Ahmad Serjouei Mahdi Bodaghi
author_sort	Ali A. Rostam-Alilou
title	Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis
title_short	Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis
title_full	Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis
title_fullStr	Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis
title_full_unstemmed	Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis
title_sort	using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: a vibro-acoustic analysis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0607c4d26f78427dba31ec10cae54d75
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Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: A vibro-acoustic analysis

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