Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes

Juan Chen,1 Yu Liu,2 Haijian Guo,3 Bei Wang,4 Zilin Sun,2 Jiangyi Yu1 1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Department of Endocrinology, Zhongda Hospi...

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Autores principales:	Chen J, Liu Y, Guo H, Wang B, Sun Z, Yu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	prediabetes lipid accumulation product uric acid urine glucose excretion Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0609d77fd27244e7aace0dd09c7d4173
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spelling	oai:doaj.org-article:0609d77fd27244e7aace0dd09c7d41732021-12-02T15:18:17ZUrine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes1178-7007https://doaj.org/article/0609d77fd27244e7aace0dd09c7d41732020-06-01T00:00:00Zhttps://www.dovepress.com/urine-glucose-excretion-attenuates-the-association-between-lipid-accum-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Juan Chen,1 Yu Liu,2 Haijian Guo,3 Bei Wang,4 Zilin Sun,2 Jiangyi Yu1 1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, People’s Republic of China; 3Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China; 4School of Public Health, Southeast University, Nanjing, People’s Republic of ChinaCorrespondence: Jiangyi YuDepartment of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu 210029, People’s Republic of ChinaTel +8613851740582Email YuJY1961@outlook.comZilin SunDepartment of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, Jiangsu, People’s Republic of ChinaTel +8613951749490Email Zilinsun1963@outlook.comPurpose: Obesity is known to be strongly associated with hyperuricemia. Moreover, the impact of urine glucose excretion (UGE) on serum uric acid (UA) levels has gained much more attention in recent years. Yet concern is raised about whether UGE influences the relationship between obesity and hyperuricemia. The aim of this study was to assess the effect of UGE on the association between lipid accumulation product (LAP), a novel marker of visceral adipose accumulation, and UA in subjects with prediabetes.Materials and Methods: Data were obtained from a cross-sectional study. A total of 3645 subjects with prediabetes were included in the present study. The separate and joint associations of LAP and UGE with hyperuricemia were examined using logistic regression analyses.Results: LAP was positively associated with UA in both genders. Subgroup analysis based on UGE revealed that the association was strongest in subjects with low UGE (r = 0.328, p < 0.001), whereas the positive association was weakened, but still remained significant in subjects with moderate and high UGE. High LAP was significantly associated with an increased odds ratio for hyperuricemia after adjustment for potential confounders in the overall population (OR = 2.07, 95% CI: 1.66– 2.58, p < 0.001). However, a downward trend in odds ratios for hyperuricemia was observed across UGE categories. In addition, the joint association analysis confirmed that the relationship between LAP and hyperuricemia was attenuated by UGE.Conclusion: The positive association between LAP and UA appears to be attenuated by UGE, indicating that promoting UGE may be an effective strategy for controlling UA levels, especially for people with obesity who are at increased risk for hyperuricemia.Keywords: prediabetes, lipid accumulation product, uric acid, urine glucose excretionChen JLiu YGuo HWang BSun ZYu JDove Medical Pressarticleprediabeteslipid accumulation producturic acidurine glucose excretionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2297-2305 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	prediabetes lipid accumulation product uric acid urine glucose excretion Specialties of internal medicine RC581-951
spellingShingle	prediabetes lipid accumulation product uric acid urine glucose excretion Specialties of internal medicine RC581-951 Chen J Liu Y Guo H Wang B Sun Z Yu J Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes
description	Juan Chen,1 Yu Liu,2 Haijian Guo,3 Bei Wang,4 Zilin Sun,2 Jiangyi Yu1 1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 2Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, People’s Republic of China; 3Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China; 4School of Public Health, Southeast University, Nanjing, People’s Republic of ChinaCorrespondence: Jiangyi YuDepartment of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu 210029, People’s Republic of ChinaTel +8613851740582Email YuJY1961@outlook.comZilin SunDepartment of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, Jiangsu, People’s Republic of ChinaTel +8613951749490Email Zilinsun1963@outlook.comPurpose: Obesity is known to be strongly associated with hyperuricemia. Moreover, the impact of urine glucose excretion (UGE) on serum uric acid (UA) levels has gained much more attention in recent years. Yet concern is raised about whether UGE influences the relationship between obesity and hyperuricemia. The aim of this study was to assess the effect of UGE on the association between lipid accumulation product (LAP), a novel marker of visceral adipose accumulation, and UA in subjects with prediabetes.Materials and Methods: Data were obtained from a cross-sectional study. A total of 3645 subjects with prediabetes were included in the present study. The separate and joint associations of LAP and UGE with hyperuricemia were examined using logistic regression analyses.Results: LAP was positively associated with UA in both genders. Subgroup analysis based on UGE revealed that the association was strongest in subjects with low UGE (r = 0.328, p < 0.001), whereas the positive association was weakened, but still remained significant in subjects with moderate and high UGE. High LAP was significantly associated with an increased odds ratio for hyperuricemia after adjustment for potential confounders in the overall population (OR = 2.07, 95% CI: 1.66– 2.58, p < 0.001). However, a downward trend in odds ratios for hyperuricemia was observed across UGE categories. In addition, the joint association analysis confirmed that the relationship between LAP and hyperuricemia was attenuated by UGE.Conclusion: The positive association between LAP and UA appears to be attenuated by UGE, indicating that promoting UGE may be an effective strategy for controlling UA levels, especially for people with obesity who are at increased risk for hyperuricemia.Keywords: prediabetes, lipid accumulation product, uric acid, urine glucose excretion
format	article
author	Chen J Liu Y Guo H Wang B Sun Z Yu J
author_facet	Chen J Liu Y Guo H Wang B Sun Z Yu J
author_sort	Chen J
title	Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes
title_short	Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes
title_full	Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes
title_fullStr	Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes
title_full_unstemmed	Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes
title_sort	urine glucose excretion attenuates the association between lipid accumulation product and serum uric acid in subjects with prediabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0609d77fd27244e7aace0dd09c7d4173
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Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes

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