Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats

Type 2 diabetes mellitus (T2DM) is a complex and polygenic disorder with diverse complications. Veratrilla baillonii Franch (V. baillonii) has been applied in the intervention and treatment a diverse range of diseases, including diabetes. In this study, we revealed that water extracts of V. bailloni...

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Autores principales:	Zhi-Hao Zhang, Juan Li, Jun Li, Zhaowu Ma, Xian-Ju Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Veratrilla baillonii franch diabetes mellitus insulin resistance diabetic liver injury transcriptome Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/060a7cfbd7f94995bde64e79b0c34b57
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spelling	oai:doaj.org-article:060a7cfbd7f94995bde64e79b0c34b572021-12-01T08:13:41ZVeratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats1663-981210.3389/fphar.2021.775563https://doaj.org/article/060a7cfbd7f94995bde64e79b0c34b572021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.775563/fullhttps://doaj.org/toc/1663-9812Type 2 diabetes mellitus (T2DM) is a complex and polygenic disorder with diverse complications. Veratrilla baillonii Franch (V. baillonii) has been applied in the intervention and treatment a diverse range of diseases, including diabetes. In this study, we revealed that water extracts of V. baillonii (WVBF) can ameliorate liver injury and insulin resistance in T2DM rat model. To elucidate the anti-diabetic mechanisms of WVBF, we performed liver transcriptome analysis that displayed WVBF treatment significantly suppressed many gene expressions involved in insulin resistance. Furthermore, functional experiments showed that WVBF treatment reduced the pathological damages of liver and pancreas, which may be regulated by Foxo1, Sirt1, G6pc, c-Met, Irs1, Akt1, Pik3r1. These results indicated that WVBF improves diabetic liver injury and insulin resistance in diabetic rats. Therefore, this study demonstrated WVBF could be used as a promising therapeutic agent for intervention and treatment of diabetes.Zhi-Hao ZhangJuan LiJun LiZhaowu MaXian-Ju HuangFrontiers Media S.A.articleVeratrilla baillonii franchdiabetes mellitusinsulin resistancediabetic liver injurytranscriptomeTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veratrilla baillonii franch diabetes mellitus insulin resistance diabetic liver injury transcriptome Therapeutics. Pharmacology RM1-950
spellingShingle	Veratrilla baillonii franch diabetes mellitus insulin resistance diabetic liver injury transcriptome Therapeutics. Pharmacology RM1-950 Zhi-Hao Zhang Juan Li Jun Li Zhaowu Ma Xian-Ju Huang Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
description	Type 2 diabetes mellitus (T2DM) is a complex and polygenic disorder with diverse complications. Veratrilla baillonii Franch (V. baillonii) has been applied in the intervention and treatment a diverse range of diseases, including diabetes. In this study, we revealed that water extracts of V. baillonii (WVBF) can ameliorate liver injury and insulin resistance in T2DM rat model. To elucidate the anti-diabetic mechanisms of WVBF, we performed liver transcriptome analysis that displayed WVBF treatment significantly suppressed many gene expressions involved in insulin resistance. Furthermore, functional experiments showed that WVBF treatment reduced the pathological damages of liver and pancreas, which may be regulated by Foxo1, Sirt1, G6pc, c-Met, Irs1, Akt1, Pik3r1. These results indicated that WVBF improves diabetic liver injury and insulin resistance in diabetic rats. Therefore, this study demonstrated WVBF could be used as a promising therapeutic agent for intervention and treatment of diabetes.
format	article
author	Zhi-Hao Zhang Juan Li Jun Li Zhaowu Ma Xian-Ju Huang
author_facet	Zhi-Hao Zhang Juan Li Jun Li Zhaowu Ma Xian-Ju Huang
author_sort	Zhi-Hao Zhang
title	Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
title_short	Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
title_full	Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
title_fullStr	Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
title_full_unstemmed	Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
title_sort	veratrilla baillonii franch ameliorates diabetic liver injury by alleviating insulin resistance in rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/060a7cfbd7f94995bde64e79b0c34b57
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Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats

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