Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.

Amino acids are essential for cell growth and proliferation for they can serve as precursors of protein synthesis, be remodelled for nucleotide and fat biosynthesis, or be burnt as fuel. Mitochondria are energy producing organelles that additionally play a central role in amino acid homeostasis. One...

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Autores principales:	Mark A Johnson, Sara Vidoni, Romina Durigon, Sarah F Pearce, Joanna Rorbach, Jiuya He, Gloria Brea-Calvo, Michal Minczuk, Aurelio Reyes, Ian J Holt, Antonella Spinazzola
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/060d119681d2428da9e75e0ee7923308
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spelling	oai:doaj.org-article:060d119681d2428da9e75e0ee79233082021-11-18T08:24:07ZAmino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.1932-620310.1371/journal.pone.0093597https://doaj.org/article/060d119681d2428da9e75e0ee79233082014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24718614/?tool=EBIhttps://doaj.org/toc/1932-6203Amino acids are essential for cell growth and proliferation for they can serve as precursors of protein synthesis, be remodelled for nucleotide and fat biosynthesis, or be burnt as fuel. Mitochondria are energy producing organelles that additionally play a central role in amino acid homeostasis. One might expect mitochondrial metabolism to be geared towards the production and preservation of amino acids when cells are deprived of an exogenous supply. On the contrary, we find that human cells respond to amino acid starvation by upregulating the amino acid-consuming processes of respiration, protein synthesis, and amino acid catabolism in the mitochondria. The increased utilization of these nutrients in the organelle is not driven primarily by energy demand, as it occurs when glucose is plentiful. Instead it is proposed that the changes in the mitochondrial metabolism complement the repression of cytosolic protein synthesis to restrict cell growth and proliferation when amino acids are limiting. Therefore, stimulating mitochondrial function might offer a means of inhibiting nutrient-demanding anabolism that drives cellular proliferation.Mark A JohnsonSara VidoniRomina DurigonSarah F PearceJoanna RorbachJiuya HeGloria Brea-CalvoMichal MinczukAurelio ReyesIan J HoltAntonella SpinazzolaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93597 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mark A Johnson Sara Vidoni Romina Durigon Sarah F Pearce Joanna Rorbach Jiuya He Gloria Brea-Calvo Michal Minczuk Aurelio Reyes Ian J Holt Antonella Spinazzola Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
description	Amino acids are essential for cell growth and proliferation for they can serve as precursors of protein synthesis, be remodelled for nucleotide and fat biosynthesis, or be burnt as fuel. Mitochondria are energy producing organelles that additionally play a central role in amino acid homeostasis. One might expect mitochondrial metabolism to be geared towards the production and preservation of amino acids when cells are deprived of an exogenous supply. On the contrary, we find that human cells respond to amino acid starvation by upregulating the amino acid-consuming processes of respiration, protein synthesis, and amino acid catabolism in the mitochondria. The increased utilization of these nutrients in the organelle is not driven primarily by energy demand, as it occurs when glucose is plentiful. Instead it is proposed that the changes in the mitochondrial metabolism complement the repression of cytosolic protein synthesis to restrict cell growth and proliferation when amino acids are limiting. Therefore, stimulating mitochondrial function might offer a means of inhibiting nutrient-demanding anabolism that drives cellular proliferation.
format	article
author	Mark A Johnson Sara Vidoni Romina Durigon Sarah F Pearce Joanna Rorbach Jiuya He Gloria Brea-Calvo Michal Minczuk Aurelio Reyes Ian J Holt Antonella Spinazzola
author_facet	Mark A Johnson Sara Vidoni Romina Durigon Sarah F Pearce Joanna Rorbach Jiuya He Gloria Brea-Calvo Michal Minczuk Aurelio Reyes Ian J Holt Antonella Spinazzola
author_sort	Mark A Johnson
title	Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
title_short	Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
title_full	Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
title_fullStr	Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
title_full_unstemmed	Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
title_sort	amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/060d119681d2428da9e75e0ee7923308
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Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.

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